{"1":{"id":"1","pmid":"24630725","doi":"10.1016\/j.cell.2014.01.056","publication_year":"2014","title":"S-glutathionylation of cryptic cysteines enhances titin elasticity by blocking protein folding","journal_title":"Cell","issn":"1097-4172","essn":"","url":"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0092867414001500","pages":"1235-1246","issue":"6","volume":"156","journal_abbr":"Cell","extra":"PMID: 24630725  PMCID: PMC3989842","publication_type":"unknown","authors":"Jorge Alegre-Cebollada, Pallav Kosuri, David Giganti, Edward Eckels, Jaime Andres Rivas-Pardo, Nazha Hamdani, Chad M. Warren, R. John Solaro, Wolfgang A. Linke, Julio M. Fernandez,","first_author":"Alegre-Cebollada","last_author":"Fernandez","antibody_info":"S-glutathionylation was detected using anti-GSH monoclonal antibodies (Virogen). Suppl.: The membranes were probed first with an anti-glutathione specific antibody (Virogen) 1:1000 then stripped and reprobed with an anti-titin (9D10) specific antibody 1:1000 (Wang et al., 1988) and with an anti-myosin heavy chain specific antibody 1:2000 (MF20) (Bader et al., 1982). The secondary antibody used for all the experiments was an anti-mouse (Sigma #A-2304) conjugated to HRP","gene_prot":"titin; actin; ryanodine receptor 2; troponin I; myosin-binding protein C; GRX; SUMO-I91; Q8WZ42; N2B; PEVK;","animals":null,"cell_lines":null,"links":null,"protocols":"Protein Expression and Purification; Measurement of I91 Cysteine Accessibility to GSSG; Single-Molecule Atomic Force Microscopy; Cardiomyocyte Elasticity Tests; Detection of S-glutathionylated Titin in Native Cardiac Tissue; Homology Modeling; Computational Prediction of Cryptic Cysteines; Purification of the SUMO-I91 Protein; Kinetic Model; Reversal of S-Glutathionylation by GRX; Monte Carlo Simulations;","wg":"ag_linke","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"2":{"id":"2","pmid":null,"doi":"10.1007\/s12268-014-0439-9","publication_year":"2014","title":"Ins Herz des sekretorischen Pfades: Stress mobilisiert Ionenkan\u00e4le","journal_title":"BIOspektrum","issn":"0947-0867, 1868-6249","essn":"","url":"http:\/\/link.springer.com\/article\/10.1007\/s12268-014-0439-9","pages":"271-274","issue":"3","volume":"20","journal_abbr":"Biospektrum","extra":"","publication_type":"unknown","authors":"Eric Arakel, Blanche Schwappach,","first_author":"Arakel","last_author":"Schwappach","antibody_info":null,"gene_prot":"SUR1; SUR2; Kir6.2; RyR2; SERCA; GPR15; ADAM22; SUR2A;","animals":null,"cell_lines":null,"links":null,"protocols":null,"wg":"ag_schwappach","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"3":{"id":"3","pmid":"24569881","doi":"10.1242\/jcs.141440","publication_year":"2014","title":"Tuning the electrical properties of the heart by differential trafficking of KATP ion channel complexes","journal_title":"Journal of Cell Science","issn":"0021-9533, 1477-9137","essn":null,"url":"http:\/\/jcs.biologists.org\/content\/127\/9\/2106","pages":"2106-2119","issue":"9","volume":"127","journal_abbr":"J Cell Sci","extra":"PMID: 24569881","publication_type":"journal_article","authors":"Eric C. Arakel, S\u00f6ren Brandenburg, Keita Uchida, Haixia Zhang, Yu-Wen Lin, Tobias Kohl, Bianca Schrul, Matthew S. Sulkin, Igor R. Efimov, Colin G. Nichols, Stephan E. Lehnart, Blanche Schwappach,","first_author":"Arakel","last_author":"Schwappach","antibody_info":"Santa Cruz Biotechnology, inc. SC-1657, SC-629, SC-1020, SC-21712, SC-568, SC-33702; Neuromab 75-267, 73-267, 75-296, 73-296; Swant 11-13; Alomone Labs ASC-005; BD Transduction Laboratories 611434\/612260; Biotrend Chemikalien GmbH 5G4-6C5; Roche 11814508001; Sigma G-2279; Badrilla Ltd. A-010-12; Abcam ab2865; Cell Signaling Technology #2729, #9624\n(Arakel_24569881_Suupl_JCS141440.pdf: Table 1)","gene_prot":"SUR1; SUR2; Kir6.1; Kir6.2; GLUT4; TRPC5; KCNJ8; KCNJ11; ABCC8; ABCC9; SUR2A; PNG F; NCX1; Abcc8; Kcnj11; b1-AR; b-DG; Na,K; GAPDH; PLN; PLN pS16; PKA; PKA pSub Ab; TASK-1; GM130; p115; 14-3-3e; 14-3-3g; PDE; PDE4; RyR2; SERCA;","animals":"Male wild-type, Kir6.2 knockout (Kcnj112\/2; described previously by Miki et al., 1998) and sulfonylurea receptor type-1 (SUR1) knockout (Abcc82\/2; described previously by Shiota et al., 2002) mice in the C57BL\/6J background,  aged 8\u201314 weeks, were used.","cell_lines":"cardiomyocytes; myocytes; HEK293T cells; Mouse atrial or ventricular myocytes","links":"http:\/\/jcs.biologists.org\/lookup\/suppl\/doi:10.1242\/jcs.141440\/-\/DC1","protocols":"Cardiac tissue and myocyte preparation; Indirect immunofluorescence microscopy; Image acquisition and colocalization analysis; Western blot detection; Crude membrane preparation; Fourier transform analysis; Membrane solubilization; Immuno-transmission electron microscopy; Glycosidase treatment; Lectin binding assay; mRNA analysis; Mal-PEG cell surface labeling assay; Recombinant expression of proteins and purification from E. coli; Binding assays; Optical measurements of action potential duration; Phos-tag PAGE; In vitro phosphorylation of membranes; Immobilized metal affinity chromatography; Immunoprecipitation; Electrophysiology;","wg":"ag_ebert, ag_schwappach","subproject":null,"open_access":"1","peer_reviewed":"2","creation_time":"2024-03-20 12:46:46"},"4":{"id":"4","pmid":"25373878","doi":"10.1007\/s10974-014-9392-y","publication_year":"2014","title":"Emerging importance of oxidative stress in regulating striated muscle elasticity","journal_title":"Journal of Muscle Research and Cell Motility","issn":"","essn":"","url":"http:\/\/link.springer.com\/article\/10.1007\/s10974-014-9392-y\/fulltext.html","pages":"","issue":null,"volume":null,"journal_abbr":"J Muscle Res Cell Motil","extra":"","publication_type":"unknown","authors":"Lisa Beckendorf, Wolfgang A. Linke,","first_author":"Beckendorf","last_author":"Linke","antibody_info":null,"gene_prot":"PKG; Nox; XO; eNOS; iNOS; nNOS; MAO; SOD; catalase; thioredoxins; actin; Tm; TnI; TnC; MLC1; MLC2; MHC; MyBP-C; titin; N2B; N2-A; N2-B; N2-Bus; N2BA; N2B; MMP2; calpain-1; \u03b1-actinin; sHSP; \u03b1B-crystallin; HSP27; PKA; PKG; PKC; CaMKII;","animals":null,"cell_lines":null,"links":null,"protocols":null,"wg":"ag_linke","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"5":{"id":"5","pmid":"24190960","doi":"10.1161\/CIRCULATIONAHA.113.004940","publication_year":"2014","title":"Enhanced expression of \u03b23-adrenoceptors in cardiac myocytes attenuates neurohormone-induced hypertrophic remodeling through nitric oxide synthase","journal_title":"Circulation","issn":"1524-4539","essn":"","url":"http:\/\/circ.ahajournals.org\/content\/129\/4\/451.abstract","pages":"451-462","issue":"4","volume":"129","journal_abbr":"Circulation","extra":"PMID: 24190960","publication_type":"unknown","authors":"Catharina Belge, Joanna Hammond, Emilie Dubois-Deruy,Boris Manoury, Julien Hamelet, Christophe Beauloye, Andreas Markl, Anne-Catherine Pouleur, Luc Bertrand, Hrag Esfahani, Karima Jnaoui, Konrad R. G\u00f6tz, Viacheslav O. Nikolaev, Annelies Vanderper, Paul Herijgers, Irina Lobysheva, Guido Iaccarino, Denise Hilfiker-Kleiner, Genevi\u00e8ve Tavernier, Dominique Langin, DVM, Chantal Dessy, Jean-Luc Balligand,","first_author":"Belge","last_author":"Balligand","antibody_info":"Invitrogen C11252, A11077, A11031; BD Biosciences 610297, 610421, 610308, 610419; Sigma A7811; Jackson ImmunoResearch Laboratories Inc. 115-005-003, 112-005-003\n(Belge_24190960_004940_supplemental_material.pdf: Supplementary Table 1: Antibodies)","gene_prot":"\u03b23-TG; \u03b23-AR; h\u03b23-AR;NOS; caveolin-3; Isolectin B4; wheat germ agglutinin; Hsp90; eNOS; cav-3; cav3; TGF\u2013\u03b21; \u03b2-MHC; GFP; GFP-av; Akt; ERK; P38; MAPK; PKG1\u03b1; calcineurin-NFAT;","animals":"Male mice harboring an \u03b1-myosin heavy chain\u2013driven human \u03b23-AR transgene (TG) were used between 12 to 16 weeks of age. heterozygote male TG and wild-type (WT) littermate controls of identical age and sex were used. Mice with a systemic deletion of \u03b23-AR (\u03b23-KO) and their WT littermate (in FVB background) were also used. \u03b23-TG and \u03b23-KO were crossbred with mice harboring a transgene coding for a FRET sensor specific for cGMP (redcGES-DE5 mice to generate \u03b23-AR0\/+; redcGES-DE50\/+ or \u03b23-AR\u2212\/\u2212; redcGES-DE50\/+ and their respective littermate controls.","cell_lines":"In Vitro Cardiac Myocytes (AMVM); adult ventricular myocytes","links":null,"protocols":"Neurohormonal Stimulation; Subcellular Fractionation, Western Blotting, and Proximity Ligation Assay; FRET Measurements; Quantitative Polymerase Chain Reaction; Echocardiographic and Hemodynamic Measurements; Histological Analyses and Immunostaining; In Vitro Cardiac Myocytes Preparations; Measurements of NO by Electron Paramagnetic Resonance;","wg":"ag_zimmermann","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"6":{"id":"6","pmid":"25049013","doi":"10.1016\/j.ijcard.2014.06.062","publication_year":"2014","title":"Increased concentration of circulating angiogenesis and nitric oxide inhibitors induces endothelial to mesenchymal transition and myocardial fibrosis in patients with chronic kidney disease","journal_title":"International Journal of Cardiology","issn":"0167-5273","essn":"","url":"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0167527314011498","pages":"99-109","issue":"1","volume":"76","journal_abbr":"Int J Cardiol","extra":"","publication_type":"unknown","authors":"David M. Charytan, Robert Padera, Alexander M. Helfand, Michael Zeisberg, Xingbo Xu, Xiaopeng Liu, Jonathan Himmelfarb, Angeles Cinelli, Raghu Kalluri, Elisabeth M. Zeisberg","first_author":"Charytan","last_author":"Zeisberg","antibody_info":null,"gene_prot":null,"animals":null,"cell_lines":null,"links":null,"protocols":null,"wg":"ag_zeisberg","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"7":{"id":"7","pmid":null,"doi":"10.4172\/2155-9880.S11-008","publication_year":"2013","title":"Cardiac Progenitor Cells and their Therapeutic Application for Cardiac Repair","journal_title":"Journal of Clinical \u0026 Experimental Cardiology","issn":"2155-9880","essn":"","url":"http:\/\/omicsonline.org\/cardiac-progenitor-cells-and-their-therapeutic-application-for-cardiac-repair-2155-9880.S11-008.php?aid=14262","pages":"","issue":null,"volume":"1","journal_abbr":"J Clin Exp Cardiolog","extra":"","publication_type":"unknown","authors":"Lukas Cyganek, Simin Chen, Thomas Borchert, Kaomei Guan,","first_author":"Cyganek","last_author":"Guan","antibody_info":null,"gene_prot":"BMP; BMP2\/4; TGF-\u03b2; Shh; FGF; FGF2\/4\/8; Wnt; Wnt3a\/8; Wnt5a; Wnt11; notch; \u03b2-catenin; Mesp1; Mesp2; Dkk1; NK2; Nkx2-5; GATA4; GATA5; Isl1; MEF2C; Tbx5; Tbx5\/20; Hand1; Hand1\/2; GATA; Fox; Tbx1\/20; FGF8\/10; Sca-1; CD34; c-Kit; CD31; CD45; CD105; CD133; CD14;","animals":null,"cell_lines":null,"links":"http:\/\/www.escardio.org\/about\/what\/advocacy\/EuroHeart\/Pages\/2012-CVD-statistics.aspx","protocols":null,"wg":"ag_guan","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"8":{"id":"8","pmid":"24928273","doi":"10.1016\/j.febslet.2014.06.006","publication_year":"2014","title":"Aim24 stabilizes respiratory chain supercomplexes and is required for efficient respiration","journal_title":"FEBS letters","issn":"1873-3468","essn":"","url":"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S001457931400458X","pages":"2985-2992","issue":"17","volume":"588","journal_abbr":"FEBS Lett","extra":"PMID: 24928273","publication_type":"unknown","authors":"Markus Deckers, Martina Balleininger, Milena Vukotic, Katharina R\u00f6mpler, Bettina Bareth, Lisa Juris, Jan Dudek,","first_author":"Deckers","last_author":"Dudek","antibody_info":"For SDS\u2013PAGE and Western blotting of proteins to polyvinylidene fluorid (PVDF) membranes standard techniques were used. Primary antibodies were raised in rabbit and secondary antibodies coupled to horseradish peroxidase.","gene_prot":"Aim24; Rcf1; Rcf2; Porin; Cyt1; Rip1; Mge1; YJR079W; Qcr6; Cox1; Cox2; Cox4; Cox5a; Atp5; Tom70; TAZ1; cytochrome c oxidase; Mic12; Mic26;","animals":null,"cell_lines":"S. cerevisiae strain BY4741 aim24D was obtained from the Euroscarf collection (Euroscarf, Frankfurt, Germany). The yeast strain Aim24GFP expressing AIM24-GFP fusion was generated by chromosomal integration.","links":null,"protocols":"Yeast strains and isolation of mitochondria; Measurement of enzymatic activities; Determination of mitochondrial respiration; In vitro import and assembly into isolated mitochondria; Microscopy; Protein isolation; Lipid extraction; SDS\u2013PAGE and Western blotting;","wg":"ag_rehling","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"9":{"id":"9","pmid":"24667282","doi":"10.1136\/heartjnl-2014-305503","publication_year":"2014","title":"The Janus face of BNP therapy in chronic heart failure: beneficial effects unmasked by \u03b2 blockers?","journal_title":"Heart","issn":"1468-201X","essn":"","url":"http:\/\/heart.bmj.com\/content\/100\/11\/819","pages":"819-820","issue":"11","volume":"100","journal_abbr":"Heart","extra":"PMID: 24667282","publication_type":"unknown","authors":"Matthias Dewenter, Christiane Vettel, Ali El-Armouche,","first_author":"Dewenter","last_author":"El-Armouche","antibody_info":null,"gene_prot":"PGK; PDE2; PDE3; NRP-A; NRP-B;","animals":null,"cell_lines":null,"links":null,"protocols":null,"wg":"ag_zimmermann","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"10":{"id":"10","pmid":"23434590","doi":"10.1172\/JCI66854","publication_year":"2013","title":"Parthenogenetic stem cells for tissue-engineered heart repair","journal_title":"Journal of Clinical Investigation","issn":"0021-9738","essn":"","url":"http:\/\/www.jci.org\/articles\/view\/66854","pages":"1285-1298","issue":"3","volume":"123","journal_abbr":"J Clin Invest","extra":"","publication_type":"unknown","authors":"Michael Didi\u00e9, Peter Christalla, Michael Rubart, Vijayakumar Muppala, Stephan D\u00f6ker, Bernhard Uns\u00f6ld, Ali El-Armouche, Thomas Rau, Thomas Eschenhagen, Alexander P. Schwoerer, Heimo Ehmke, Udo Schumacher, Sigrid Fuchs, Claudia Lange, Alexander Becker, Wen Tao, John A. Scherschel, Mark H. Soonpaa, Tao Yang, Qiong Lin, Martin Zenke, Dong-Wook Han, Hans R. Sch\u00f6ler, Cornelia Rudolph, Doris Steinemann, Brigitte Schlegelberger, Steve Kattman, Alec Witty, Gordon Keller, Loren J. Field, Wolfram-Hubertus Zimmermann,","first_author":"Didie","last_author":"Zimmermann","antibody_info":"Indicated antibodies were developed by D. Solter and B.B. Knowles (antibody against FUT4), and D.A. Fischman (antibody against myosin), and obtained from the Developmental Studies Hybridoma Bank.","gene_prot":"POU5F1; NANOG; FUT4; SSEA1; Mest; Peg3; SgcE; Plagl1; Impact; Zrsr1; Zdbf2; Nnat; Inpp5f; Peg10; Kcnq1ot1; Pon2; Grb10; Ascl2; Slc38a4; Rian; Phlda2; Meg3; Pecam1; Myh11; Kdr; Afp; Krt18; Krt10; Syp; Drd2; Myf5; Gapdh; Neb; Gata4; Nefm; Pou5fl; Sox2; Klf4; Myc; Lin28; Zfp42; Peg1; Igf2r; Dlk1; Gtl2; CTCF1; DMR2; Pou5f1; Kdr; Isl1; Nkx2-5; Myh6; Myh7; Casq2; Actinin; CD31; GFP;","animals":"6- to 8-weekold (C57BL\/6J \u00d7 DBA\/2J)F1 (B6D2F1) mice; NMRI mice","cell_lines":null,"links":"http:\/\/www.ncbi.nlm.nih.gov\/geo (Gene Expression Omnibus database: accession number GSE30868)","protocols":"Generation and culture of PSCs; In vitro differentiation of PSCs; Assessment of growth rate; Genotype analyses; Gene array analysis; DNA methylation analysis; Standard karyotyping; Spectral karyotyping (SKY); Array comparative genomic hybridization; Alkaline phosphatase activity; Confocal laser scanning microscopy; Teratoma assays; Patch-clamp experiments; Blastocyst injection; LacZ staining; Acetylcholinesterase staining; Two-photon laser scanning microscopy of intracellular calcium transients; Directed differentiation of PSC-EB cultures; EHM construction; Isometric force measurement; MI and EHM implantation; Echocardiography;","wg":"ag_zimmermann","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"11":{"id":"11","pmid":"23771692","doi":"10.1152\/ajpheart.00218.2013","publication_year":"2013","title":"Preservation of left ventricular function and morphology in volume-loaded versus volume-unloaded heterotopic heart transplants","journal_title":"American Journal of Physiology. Heart and Circulatory Physiology","issn":"0363-6135, 1522-1539","essn":"","url":"http:\/\/ajpheart.physiology.org\/content\/305\/4\/H533","pages":"H533-H541","issue":"4","volume":"305","journal_abbr":"Am J Physiol Heart Circ Physiol","extra":"Total mechanical unloading of the heart in classical models of heterotopic heart transplantation leads to cardiac atrophy and functional deterioration. In contrast, partial unloading of failing human hearts with left ventricular (LV) assist devices (LVADs) can in some patients ameliorate heart failure symptoms. Here we tested in heterotopic rat heart transplant models whether partial volume-loading (VL; anastomoses: aorta of donor to aorta of recipient, pulmonary artery of donor to left atrium of donor, superior vena cava of donor to inferior vena cava of recipient; n = 27) is superior to the classical model of myocardial unloading (UL; anastomoses: aorta of donor to aorta of recipient, pulmonary artery of donor to inferior vena cava of recipient; n = 14) with respect to preservation of ventricular morphology and function. Echocardiography, magnetic resonance imaging, and LV-pressure-volume catheter revealed attenuated myocardial atrophy with \u223c30% higher LV weight and better systolic contractile function in VL compared with UL (fractional area shortening, 34% vs. 18%; maximal change in pressure over time, 2,986 \u00b1 252 vs. 2,032 \u00b1 193 mmHg\/s). Interestingly, no differences in fibrosis (Picrosirus red staining) or glucose metabolism (2-[18F]-fluoro-2-deoxy-D-glucose-PET) between VL and UL were observed. We conclude that the rat model of partial VL attenuates atrophic remodelling and shows superior morphological as well as functional preservation, and thus should be considered more widely as a research model. PMID: 23771692","publication_type":"unknown","authors":"Michael Didi\u00e9, Daniel Biermann, Ralph Buchert, Andreas Hess, Katrin Wittk\u00f6pper, Peter Christalla, Stephan D\u00f6ker, Fawad Jebran, Friedrich Sch\u00f6ndube, Hermann Reichenspurner, Ali El-Armouche, Wolfram-Hubertus Zimmermann,","first_author":"Didie","last_author":"Zimmermann","antibody_info":null,"gene_prot":null,"animals":"adult male Wistar rats (Charles River, Sulzfeld, Germany)","cell_lines":null,"links":null,"protocols":"Animal models of heterotopic abdominal heart transplantation; Echocardiography; MRI; LV catheterization; PET; Histological assessment of cardiac fibrosis; PCR;","wg":"ag_zimmermann","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"12":{"id":"12","pmid":"23792436","doi":"10.1016\/j.scr.2013.05.005","publication_year":"2013","title":"Cardiolipin deficiency affects respiratory chain function and organization in an induced pluripotent stem cell model of Barth syndrome","journal_title":"Stem Cell Research","issn":"1876-7753","essn":"","url":"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S1873506113000548","pages":"806-819","issue":"2","volume":"11","journal_abbr":"Stem Cell Res","extra":"PMID: 23792436","publication_type":"unknown","authors":"Jan Dudek, I-Fen Cheng, Martina Balleininger, Fr\u00e9d\u00e9ric M. Vaz, Katrin Streckfuss-B\u00f6meke, Daniela H\u00fcbscher, Milena Vukotic, Ronald J.A. Wanders, Peter Rehling, Kaomei Guan","first_author":"Dudek","last_author":"Guan","antibody_info":"Proteins were bound to polyvinylidene fluoride (PVDF) membranes by Westernblotting and probed using primary antibodies raised in rabbit and secondary antibodies coupled to horseradish peroxidase.","gene_prot":"OCT4; SOX2; KLF4; c-MYC; TAZ1; LIN28; NANOG; \u03b1-SMA; AFP; \u03b2-III tubulin; SSEA-4; TRA-1-60; COX1; COX4-I; COX5A; COX6A; NDUFB8; VDAC; Rieske; TOM40; TIM23;","animals":null,"cell_lines":"Dermal fibroblasts were obtained from 3 patients diagnosed with BTHS (Table 1) and 1 healthy donor (Houtkooper et al., 2009).","links":null,"protocols":"Generation and culture of BTHS\u2013iPSCs; Genomic sequencing; Pluripotency characterization of iPSCs; Determination of respiratory capacity; Mass spectrometry analysis of CL and monolysocardiolipin (MLCL); Membrane potential measurement; Blue native PAGE; Isolation of mitochondria from BTHS and control iPSCs;","wg":"ag_guan","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"13":{"id":"13","pmid":"24812278","doi":"10.1093\/cvr\/cvu120","publication_year":"2014","title":"Tubulin polymerization disrupts cardiac \u03b2-adrenergic regulation of late INa","journal_title":"Cardiovascular Research","issn":"0008-6363, 1755-3245","essn":"","url":"http:\/\/cardiovascres.oxfordjournals.org\/content\/early\/2014\/05\/08\/cvr.cvu120","pages":"cvu120","issue":null,"volume":null,"journal_abbr":"Cardiovasc Res","extra":"Aims The anticancer drug paclitaxel (TXL) that polymerizes microtubules is associated with arrhythmias and sinus node dysfunction. TXL can alter membrane expression of Na channels (NaV1.5) and Na current (INa) but the mechanisms are unknown. Ca\/CaM-dependent protein kinase II (CaMKII) can be activated by \u03b2-adrenergic stimulation and regulates INa gating. We tested, whether TXL interferes with isoproterenol (ISO)-induced activation of CaMKII and consequent INa regulation. Methods and Results In wild-type (WT) mouse myocytes, the addition of ISO (1 \u00b5mol\/L) resulted in increased CaMKII autophosphorylation (Western blotting). This increase was completely abolished after pre-treatment with TXL (100 \u00b5mol\/L, 1.5 h). The mechanism was further investigated in human embryonic kidney cells. TXL inhibited the ISO-induced \u03b2-arrestin translocation. Interestingly, both knockdown of \u03b2-arrestin 2 expression using small interfering RNA or inhibition of exchange protein directly activated by cAMP (Epac) blocked the ISO-induced CaMKII autophosphorylation similar to TXL. The generation of cAMP, however, was unaltered (Epac1-camps). CaMKII-dependent Na channel function was measured using patch-clamp technic in isolated cardiomyoctes. ISO stimulation failed to induce CaMKII-dependent enhancement of late INa and Na channel inactivation (negative voltage shift in steady-state activation and enhanced intermediate inactivation) after TXL pre-incubation. Consistent with this, TXL also inhibited ISO-induced CaMKII-specific Na channel phosphorylation (at serine 571 of NaV1.5). Conclusion TXL preincubation disrupts the ISO-dependent CaMKII activation and consequent Na channel regulation. This may be important for patients receiving TXL treatments but also relevant for conditions of increased CaMKII expression and enhanced \u03b2-adrenergic stimulation like in heart failure. PMID: 24812278","publication_type":"unknown","authors":"Nataliya Dybkova, Stefan Wagner, Johannes Backs, Thomas J. Hund, Peter J. Mohler, Thomas Sowa, Viacheslav O. Nikolaev, Lars S. Maier,","first_author":"Dybkova","last_author":"Maier","antibody_info":"mouse monoclonal anti-phospho-CaMKII (1:1000, Thermo Scientific), rabbit polyclonal anti-CaMKII (1:15000, gift from D. M. Bers, University of California, Davis, CA, USA), rabbit polyclonal anti-phospho-NaV1.5 S-571 (1:1000), rabbit polyclonal anti-NaV1.5 (1:10000, gift from P. J. Mohler, Carver College of Medicine, University of Iowa, Iowa City, IA, USA), mouse monoclonal anti-\u03b2-arrestin2 (1:600, Santa Cruz Biotechnology), and mouse monoclonal anti-GAPDH (1:100000, BIOTREND); Secondary antibodies were HRP-conjugated donkey anti-rabbit and sheep anti-mouse IgG (1:10000, GE Healthcare); rabbit polyclonal anti-CaMKII (1:100, gift from D. M. Bers, University of California, Davis, CA, USA), mouse monoclonal anti-phospho-CaMKII (1:100, Thermo Scientific), rabbit polyclonal anti-phospho-NaV1.5 S-571 (1:100) and rabbit polyclonal anti-NaV1.5 (1:100, gift from P. J. Mohler, Carver College of Medicine, University of Iowa, Iowa City, IA, USA), or goat polyclonal anti-\u03b2-tubulin (1:100, Abcam); dye-conjugated secondary antibodies: Alexa 555-conjugated goat anti-mouse, Alexa 488-conjugated goat anti-rabbit (1:200, InvitrogenTM Molecular Probes), or Alexa 546-conjugated rabbit anti-goat (1:600,  InvitrogenTM Molecular Probes);","gene_prot":"NaV1.5; CaMKII; p-CaMKII; Epac; b-arrestin2; GRK;","animals":"11-16 weeks old CaMKII  knockout mice (CaMKII -\/-, 37 mice)15 were compared with their age and sex-matched wild-type (WT) littermates (40 mice).","cell_lines":"HEK293a cells; CaMKII -\/- myocytes","links":null,"protocols":"Myocyte isolation and incubation with microtubule stabilizer paclitaxel; Measurement of ISO-induced  -arrestin translocation; Measurement of cAMP generation using Fluorescence-Resonance Energy Transfer (FRET); Patch-Clamp Experiments; Western Blots and Immunocytochemical staining;","wg":"ag_sossalla","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"14":{"id":"14","pmid":"23877259","doi":"10.1161\/CIRCULATIONAHA.113.001746","publication_year":"2013","title":"Ca2+\/calmodulin-dependent protein kinase II and protein kinase A differentially regulate sarcoplasmic reticulum Ca2+ leak in human cardiac pathology","journal_title":"Circulation","issn":"1524-4539","essn":"","url":"http:\/\/circ.ahajournals.org\/content\/128\/9\/970","pages":"970-981","issue":"9","volume":"128","journal_abbr":"Circulation","extra":"PMID: 23877259","publication_type":"unknown","authors":"Thomas H. Fischer, Jonas Herting, Theodor Tirilomis, Andr\u00e9 Renner, Stefan Neef, Karl Toischer, David Ellenberger, Anna F\u00f6rster, Jan D. Schmitto, Jan Gummert, Friedrich A. Sch\u00f6ndube, Gerd Hasenfuss, Lars S. Maier, Samuel Sossalla,","first_author":"Fischer","last_author":"Sossalla","antibody_info":"anti-TnI (1:1000; Cell Signaling Technology, Danvers, MA), anti-phospho-TnI Ser23\/24 (1:1000; Cell Signaling Technology), anti-RyR2 (1:10 000; Sigma-Aldrich, St Louis, MO), anti-phospho-RyR2 2809 (1:5000; Badrilla, Leeds, United Kingdom), anti-phospho-RyR2 Ser2815 (1:5000; Badrilla), and anti-GAPDH (1:20 000; Biotrend Chemikalien GmbH, K\u00f6ln, Germany) antibodies;","gene_prot":"RyR2; CaMKII; PKA; GAPDH; TnI; calsequestrin;","animals":null,"cell_lines":"Left ventricular myocardial tissue; elongated, non-granulated cardiomyocytes","links":"http:\/\/circ.ahajournals.org\/content\/suppl\/2013\/07\/19\/CIRCULATIONAHA.113.001746.DC1.html","protocols":"Heart Failure; Cardiac Hypertrophy; NF Myocardium; Western Blots; Myocyte Isolation; Intracellular Ca2+ Imaging; Confocal Microscopy (Measurement of SR Ca2+ Sparks); Epifluorescence Microscopy (Systolic Ca2+ Transients and SR Ca2+ Content);","wg":"ag_sossalla","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"15":{"id":"15","pmid":"25201344","doi":"10.1002\/ejhf.163","publication_year":"2014","title":"Ca(2+) \/calmodulin-dependent protein kinase II equally induces sarcoplasmic reticulum Ca(2+) leak in human ischaemic and dilated cardiomyopathy","journal_title":"European Journal of Heart Failure","issn":"1879-0844","essn":"","url":"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ejhf.163\/abstract","pages":"","issue":null,"volume":null,"journal_abbr":"Eur J Heart Fail","extra":"PMID: 25201344","publication_type":"unknown","authors":"Thomas H. Fischer, J\u00f6rg Eiringhaus, Nataliya Dybkova, Anna F\u00f6rster, Jonas Herting, Astrid Kleinw\u00e4chter, Senka Ljubojevic, Jan D. Schmitto, Katrin Streckfu\u00df-B\u00f6meke, Andr\u00e9 Renner, Jan Gummert, Gerd Hasenfuss, Lars S. Maier, Samuel Sossalla,","first_author":"Fischer","last_author":"Sossalla","antibody_info":"Membranes were probed with anti-RyR2 (1:10 000; Sigma-Aldrich, rabbit), anti-phospho-S2814-RyR2 (1:5000; Badrilla, rabbit), anti-phospho-S2808-RyR2 (1:5000; Badrilla, rabbit), anti-CaMKII (1:12 000; gift from D.M. Bers,  University of California, Davis, CA, USA, rabbit), anti-phospho-CaMKII (1:1000; Thermo Scientific, mouse), anti-PLB (1:10 000, Millipore, mouse), anti-phospho-Thr17-PLB (1:10 000, Badrilla, rabbit), and anti-glyceraldehyde phosphate dehydrogenase (GAPDH; 1:50 000; Biotrend, mouse) antibodies; secondary antimouse and antirabbit antibodies (GE Healthcare).","gene_prot":"CaMKII; RyR2; NCX; PLB; GAPDH; NF-\u03baB;","animals":null,"cell_lines":"Left ventricular myocardial tissue; elongated, non-granulated cardiomyocytes","links":null,"protocols":"Human myocardial tissue; Western blots; Myocyte isolation; Intracellular Ca2+ imaging; Confocal microscopy (measurement of sarcoplasmic reticulum Ca2+ sparks);","wg":"ag_sossalla","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"16":{"id":"16","pmid":"23159442","doi":"10.1016\/j.yjmcc.2012.11.003","publication_year":"2013","title":"The Ca-calmodulin dependent kinase II: A promising target for future antiarrhythmic therapies?","journal_title":"Journal of Molecular and Cellular Cardiology","issn":"0022-2828, 1095-8584","essn":"","url":"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0022282812004038","pages":"182-187","issue":null,"volume":"58","journal_abbr":"J Mol Cell Cardiol","extra":"","publication_type":"unknown","authors":"Thomas H. Fischer, Stefan Neef, Lars S. Maier,","first_author":"Fischer","last_author":"Maier","antibody_info":null,"gene_prot":"CaMKII; RyR2; SERCA2a; PLN;","animals":null,"cell_lines":null,"links":null,"protocols":null,"wg":"ag_sossalla","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"17":{"id":"17","pmid":"22932727","doi":"10.1007\/s10741-012-9339-6","publication_year":"2013","title":"The ryanodine receptor leak: how a tattered receptor plunges the failing heart into crisis","journal_title":"Heart Failure Reviews","issn":"1573-7322","essn":"","url":"http:\/\/link.springer.com\/article\/10.1007\/s10741-012-9339-6","pages":"475-483","issue":"4","volume":"18","journal_abbr":"Heart Fail Rev","extra":"PMID: 22932727  PMCID: PMC3677980","publication_type":"unknown","authors":"Thomas H. Fischer, Lars S. Maier, Samuel Sossalla,","first_author":"Fischer","last_author":"Sossalla","antibody_info":null,"gene_prot":"RyR2; PKA; CaMKII; TnC; SERCA2a; NCX; PLB; CaMKIId; Calsequestrin; junctin; triadin; FK506-binding protein; FKBP12.6; PP1; PP2a;","animals":null,"cell_lines":null,"links":null,"protocols":null,"wg":"ag_sossalla","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"18":{"id":"18","pmid":null,"doi":"","publication_year":"2014","title":"Herzinsuffizienz","journal_title":"Austrian Journal of Cardiology","issn":"1024-0098","essn":"","url":"http:\/\/www.kup.at\/journals\/summary\/12234.html","pages":"208-213","issue":"21","volume":"7","journal_abbr":"","extra":"","publication_type":"unknown","authors":"A. F\u00f6rster, L. S. Maier,","first_author":"F\u00f6rster","last_author":"Maier","antibody_info":null,"gene_prot":"CaMKIId; RyR2; SERCA-2a; PLB; ACE; NCX;","animals":null,"cell_lines":null,"links":null,"protocols":null,"wg":"ag_sossalla","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"19":{"id":"19","pmid":"23709029","doi":"10.1007\/978-1-62703-459-3_7","publication_year":"2013","title":"Advances and techniques to measure cGMP in intact cardiomyocytes","journal_title":"Methods in Molecular Biology (Clifton, N.J.)","issn":"1940-6029","essn":"","url":"http:\/\/link.springer.com\/protocol\/10.1007\/978-1-62703-459-3_7","pages":"121-129","issue":null,"volume":"1020","journal_abbr":"Methods Mol Biol","extra":"PMID: 23709029","publication_type":"unknown","authors":"Konrad R. G\u00f6tz, Viacheslav O. Nikolaev,","first_author":"G\u00f6tz","last_author":"Nikolaev","antibody_info":null,"gene_prot":"PDE2;","animals":null,"cell_lines":"adult mouse ventricular myocytes","links":null,"protocols":"Cardiomyocyte Isolation; Heart Perfusion System; FRET Imaging System;","wg":"ag_zimmermann","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"20":{"id":"20","pmid":"24599804","doi":"10.1161\/CIRCRESAHA.114.302437","publication_year":"2014","title":"Transgenic Mice for Real-Time Visualization of cGMP in Intact Adult Cardiomyocytes","journal_title":"Circulation Research","issn":"0009-7330, 1524-4571","essn":"","url":"http:\/\/circres.ahajournals.org\/content\/114\/8\/1235","pages":"1235-1245","issue":"8","volume":"114","journal_abbr":"Circ Res","extra":"PMID: 24599804","publication_type":"unknown","authors":"Konrad R. G\u00f6tz, Julia U. Sprenger, Ruwan K. Perera, Julia H. Steinbrecher, Stephan E. Lehnart, Michaela Kuhn, Julia Gorelik, Jean-Luc Balligand and Viacheslav O. Nikolaev,","first_author":"G\u00f6tz","last_author":"Nikolaev","antibody_info":"NO-GCa1 and NO-GCb1 rabbit polyclonal antibodies (both antibodies together with the recombinant NO-GCb1 protein were kindly provided by Stepan Gambaryan and Andreas Friebe, University of W\u00fcrzburg, antibody dilution 1:2000); anti-P-Ser16 phospholamban (Badrilla 1:5000), anti-GAPDH (HyTest, 1:80.000), and anti-\uf061-tubulin (Sigma, 1:5000) antibodies; anti-PLN A-1 antibody (Badrilla, 1:2500);","gene_prot":"PDE; PDE1; PDE2; PDE3; PDE5;","animals":"FVB\/NRj background (obtained from Janvier Laboratories, Saint Berthevin, France) as described.30","cell_lines":"cardiomyocytes","links":"http:\/\/circres.ahajournals.org\/content\/suppl\/2014\/03\/05\/CIRCRESAHA.114.302437.DC1.html","protocols":"Transverse Aortic Constriction; Genotyping of transgenic mice; Histology, Morphometric analysis and Echocardiography; Cardiomyocyte isolation; Confocal microscopy; FRET analysis; Working heart experiments; cGMP radioimmunoassay; PDE activity assay; Immunoblot analysis;","wg":"ag_zimmermann","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"21":{"id":"21","pmid":null,"doi":"10.1007\/s11825-013-0403-y","publication_year":"2013","title":"Archivierung von Genomdaten","journal_title":"Medizinische Genetik","issn":"0936-5931, 1863-5490","essn":null,"url":"http:\/\/link.springer.com\/article\/10.1007\/s11825-013-0403-y","pages":"388-394","issue":"3","volume":"25","journal_abbr":"medgen","extra":null,"publication_type":"unknown","authors":"R. Gr\u00fctz; N. Mathieu; B. L\u00f6hnhardt; P. Weil; M. Krawczak;","first_author":"Gr\u00fctz","last_author":"Krawczak","antibody_info":null,"gene_prot":null,"animals":null,"cell_lines":null,"links":null,"protocols":null,"wg":"ag_nussbeck","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"22":{"id":"22","pmid":"23213108","doi":"10.1093\/cvr\/cvs353","publication_year":"2013","title":"Deranged myofilament phosphorylation and function in experimental heart failure with preserved ejection fraction","journal_title":"Cardiovascular Research","issn":"0008-6363, 1755-3245","essn":"","url":"http:\/\/cardiovascres.oxfordjournals.org\/content\/97\/3\/464","pages":"464-471","issue":"3","volume":"97","journal_abbr":"Cardiovasc Res","extra":"Aims Heart failure (HF) with preserved ejection fraction (HFpEF) is a major cause of morbidity and mortality. Key alterations in HFpEF include increased left ventricular (LV) stiffness and abnormal relaxation. We hypothesized that myofilament protein phosphorylation and function are deranged in experimental HFpEF vs . normal myocardium. Such alterations may involve the giant elastic protein titin, which contributes decisively to LV stiffness. Methods and results LV tissue samples were procured from normal dogs (CTRL) and old dogs with hypertension-induced LV hypertrophy and diastolic dysfunction (OHT\/HFpEF). We quantified the expression and phosphorylation of myofilament proteins, including all-titin and site-specific titin phosphorylation, and assessed the expression\/activity of major protein kinases (PKs) and phosphatases (PPs), myofilament calcium sensitivity (pCa50), and passive tension (Fpassive) of isolated permeabilized cardiomyocytes. In OHT vs . CTRL hearts, protein kinase-G (PKG) activity was decreased, whereas PKC\u03b1 activity and PP1\/PP2a expression were increased. Cardiac MyBPC, TnT, TnI and MLC2 were less phosphorylated and pCa50 was increased in OHT vs . CTRL. The titin N2BA (compliant) to N2B (stiff) isoform-expression ratio was lowered in OHT. Hypophosphorylation in OHT was detected for all-titin and at serines S4010\/S4099 within titin-N2Bus, whereas S11878 within proline, glutamate, valine, and lysine (PEVK)-titin was hyperphosphorylated. Cardiomyocyte Fpassive was elevated in OHT, but could be normalized by PKG or PKA, but not PKC\u03b1, treatment. Conclusions This patient-mimicking HFpEF model is characterized by titin stiffening through altered isoform composition and phosphorylation, both contributing to increased LV stiffness. Hypophosphorylation of myofilament proteins and increased calcium sensitivity suggest that functional impairment at the sarcomere level may be an early event in HFpEF. PMID: 23213108","publication_type":"unknown","authors":"Nazha Hamdani, Kalkidan G. Bishu, Marion von Frieling-Salewsky, Margaret M. Redfield, Wolfgang A. Linke,","first_author":"Hamdani","last_author":"Linke","antibody_info":"Affinity-purified phosphospecific and sequence-specific antititin antibodies were custom-made by Eurogentec (Belgium).","gene_prot":"MyBPC; cMyBPC; TnT; TnI; MLC2; cMLC2; N2BA; N2B; N2Bus; PKG; PKA; PKC\u03b1; PDE5A; titin; PP1; PP2a; Q8WZ42;","animals":null,"cell_lines":null,"links":null,"protocols":"Titin isoform separation; Total protein phosphorylation assays; Immunoblotting; Myocardial protein kinase G and A activity tests; Force measurements on isolated skinned cardiomyocytes;","wg":"ag_linke","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"23":{"id":"23","pmid":"23283722","doi":"10.1161\/CIRCRESAHA.111.300105","publication_year":"2013","title":"Crucial role for Ca2(+)\/calmodulin-dependent protein kinase-II in regulating diastolic stress of normal and failing hearts via titin phosphorylation","journal_title":"Circulation Research","issn":"0009-7330","essn":"","url":"http:\/\/circres.ahajournals.org\/content\/112\/4\/664\/suppl\/DC1","pages":"664-674","issue":"4","volume":"112","journal_abbr":"Circ Res","extra":"PMID: 23283722","publication_type":"unknown","authors":"Nazha Hamdani, Judith Krysiak, Michael M. Kreusser, Stefan Neef, Cristobal G. dos Remedios, Lars S. Maier, Markus Kr\u00fcger, Johannes Backs, Wolfgang A. Linke,","first_author":"Hamdani","last_author":"Linke","antibody_info":"custom-made, affinity-purified, phosphoserine-specific antibodies against phospho-S4010, -S4062, -S4099 (all N2Bus), -S11878, and -S12022 (both PEVK), of human titin (UniProtKB identifyer, Q8WZ42), and antibodies  recognizing the corresponding nonphosphorylated sequence at these sites. We also used phosphosite-specific antibodies against phospho-S3991, -S4043, -S4080 (all N2Bus), -S12742, and -S12884 (both PEVK), of mouse titin (UniProtKB identifyer, A2ASS6)","gene_prot":"CaMKII\u03b4; CaMKII\u03b3; CaMKII\u03b4C; CaMKI; PEVK; titin; N2A; N2B; PKG; ERK2; PK-II; Q8WZ42; A2ASS6; PKA; PKC\u03b1;","animals":"CaMKII\u03b4\/\u03b3 double knockout mice (DKO), the previously established and characterized CaMKII\u03b4C-overexpressing transgenic (TG) mice","cell_lines":"Left-ventricular tissue","links":"http:\/\/circres.ahajournals.org\/content\/suppl\/2013\/01\/02\/CIRCRESAHA.111.300105.DC1.html","protocols":"Quantitative Mass Spectrometry; Titin Analysis; Titin Isoform Separation; All-Titin Phosphorylation Assays; Titin\/Phosphotitin Immunoblots; Recombinant Titin Construct Expression and Phosphorylation; Cardiomyocyte Force Measurements; CaMKII Expression and Activity; Prediction of CaMK-Dependent Phosphosites;","wg":"ag_linke","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"24":{"id":"24","pmid":"23740213","doi":"10.1007\/s00395-013-0355-z","publication_year":"2013","title":"Special issue \u0022Novel perspectives on heart failure\u0022","journal_title":"Basic Research in Cardiology","issn":"1435-1803","essn":"","url":"http:\/\/link.springer.com\/article\/10.1007%2Fs00395-013-0355-z","pages":"355","issue":"4","volume":"108","journal_abbr":"Basic Res Cardiol","extra":"PMID: 23740213","publication_type":"unknown","authors":"G. Hasenfu\u00df, G. Heusch,","first_author":"Hasenfu\u00df","last_author":"Heusch","antibody_info":null,"gene_prot":"NADPH oxidase; calcium-calmodulin-dependent kinase;","animals":null,"cell_lines":null,"links":null,"protocols":null,"wg":"ag_hasenfuss","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"25":{"id":"25","pmid":"24051368","doi":"10.1016\/j.yjmcc.2013.09.006","publication_year":"2013","title":"Function and regulation of serine\/threonine phosphatases in the healthy and diseased heart","journal_title":"Journal of Molecular and Cellular Cardiology","issn":"0022-2828, 1095-8584","essn":"","url":"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0022282813002691","pages":"90-98","issue":null,"volume":"64","journal_abbr":"J Mol Cell Cardiol","extra":"PMID: 24051368","publication_type":"unknown","authors":"Jordi Heijman, Matthias Dewenter, Ali El-Armouche, Dobromir Dobrev,","first_author":"Heijman","last_author":"Dobrev","antibody_info":null,"gene_prot":"PP1; PP2; PP2A; PP2B; PP2C; calcineurin; PP1\u03b1; PP1\u03b3; PP1\u03b4; PP1\u03b2; PP2A-C; PP2A-A; PP2A-A\u03b1; PP2A-A\u03b2; PP2AC\u03b1; PP2A-C\u03b2; PP2A-B; PP2A-B\u2032; PP2A-B\u2033; PP2A-B\u2034; PPP2R5A; PP2A-B\u2032\u03b1; B56\u03b1; B56\u03b5; B55\u03b1; B56\u03b3; B56\u03b5; PR72\/PR130; B56\u03b3; PR53; CNA; CNB; CNA\u03b1; CNA\u03b2; CNA\u03b3; AKAP79; Cain; NaV1.5; PKA; CaMKII; RyR2; Spino; Ank-B; mAKAB; CSQ2; AKAP18; RGL; Yotiao; MyBP-C; titin; NCX1; KCNQ1; AKAP9; Ankyrin-B; SERCA2a; PLB; phospholemman; CKIP-1; GADD34; eIF2\u03b1; MYPT2; I-1; I-2; Spinophilin;","animals":null,"cell_lines":null,"links":"http:\/\/dx.doi.org\/10.1016\/j.yjmcc.2013.09.006","protocols":null,"wg":"ag_zimmermann","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"26":{"id":"26","pmid":"23504549","doi":"10.1093\/cvr\/cvt058","publication_year":"2013","title":"Imaging T-tubules: dynamic membrane structures for deep functions","journal_title":"Cardiovascular Research","issn":"0008-6363, 1755-3245","essn":"","url":"http:\/\/cardiovascres.oxfordjournals.org\/content\/98\/2\/162","pages":"162-164","issue":"2","volume":"98","journal_abbr":"Cardiovasc Res","extra":"This editorial refers to \u2018Emerging mechanisms of T-tubule remodelling in heart failure\u2019 by A. Guo et al ., pp. 204\u2013215, this issue and \u2018Ultrastructural uncoupling between T-tubules and sarcoplasmic reticulum in human heart failure\u2019 by H.-B. Zhang, et al ., pp. 269\u2013276, this issue.  Extensive intracellular contacts of the endo\/sarcoplasmic reticulum (ER\/SR) with transverse tubules (TTs) are fundamental for intracellular Ca2+ cycling in cardiac muscle. For this, TTs extend from the cytoplasmic surface deep into the cell, setting up a complex three-dimensional (3D) membrane network, referred to as \u2018transverse axial tubular system\u2019 (TATS) ( Figure\u00a01 A ). The TATS extends over several orders of magnitude in size, e.g. from local TT diameters \u003C100 nm to cell-wide continuous networks expanding over 100 \u03bcm, in order to provide thousands of subcellular TT contacts with the ER organelle via junctional SR (jSR) contacts in a typical ventricular myocyte (VM). Not surprisingly, approaches to study the TT membrane structures and properties of the TATS network encompass different imaging and physiological methods. However, until recently ultrastructural TT resolution vs. continuous representation of TATS regions had to be traded against each other. Just imagine representative EM studies (smallest field of view, possible resolution \u22641 nm) when compared with confocal fluorescence microscopy of histological samples (field of view of \u223c150 \u00d7 150 \u00b5m at \u223c250 nm resolution using \u00d763 objectives). Meanwhile this methodological gap is addressed by recent super-resolution fluorescence microscopy approaches (see below).1 Despite apparent gaps between imaging resolution and the nanometric nature of subcellular membrane compartments, conventional fluorescence microscopy is essential to characterize TATS membranes in living samples. In particular, functional imaging studies of isolated cells and two-photon imaging of intact heart tissue have related typical TATS architectures to subcellular functions like Ca2+ release events (sparks) in resting cells (for diastole) or Ca2+ transients \u2026 PMID: 23504549","publication_type":"unknown","authors":"Tobias Kohl, Stephan E. Lehnart","first_author":"Kohl","last_author":"Lehnart","antibody_info":null,"gene_prot":"CaV1.2; RyR2; Cav3;","animals":null,"cell_lines":null,"links":null,"protocols":null,"wg":"ag_lehnart","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"27":{"id":"27","pmid":"23219451","doi":"10.1016\/j.yjmcc.2012.11.016","publication_year":"2013","title":"Superresolution microscopy in heart - cardiac nanoscopy","journal_title":"Journal of Molecular and Cellular Cardiology","issn":"0022-2828, 1095-8584","essn":"","url":"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S002228281200421X","pages":"13-21","issue":null,"volume":"58","journal_abbr":"J Mol Cell Cardiol","extra":"PMID: 23219451","publication_type":"unknown","authors":"Tobias Kohl, Volker Westphal, Stefan W. Hell, Stephan E. Lehnart,","first_author":"Kohl","last_author":"Lehnart","antibody_info":null,"gene_prot":"VDAC; hexokinase; Eos2; Dronpa; PS-CFP2; FKBP; RyR2; JPH2; RyR1;","animals":null,"cell_lines":null,"links":null,"protocols":null,"wg":"ag_lehnart","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"28":{"id":"28","pmid":"24631768","doi":"10.1016\/j.yjmcc.2014.03.001","publication_year":"2014","title":"Reactive oxygen species and excitation-contraction coupling in the context of cardiac pathology","journal_title":"Journal of Molecular and Cellular Cardiology","issn":"0022-2828, 1095-8584","essn":"","url":"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S002228281400073X","pages":"92-102","issue":null,"volume":"73","journal_abbr":"J Mol Cell Cardiol","extra":"PMID: 24631768","publication_type":"unknown","authors":"Anne C. K\u00f6hler, Can M. Sag, Lars S. Maier,","first_author":"K\u00f6hler","last_author":"Maier","antibody_info":null,"gene_prot":"CaMKII; CaMKII\u03b4C; PKA; PKC; PKC-\u03b1; PKC-\u03b22; RyR2; PP1; PP2A; PLB; PLB-P; SERCA; NCX; LTCC; Nav1.5; Troponin I; SERCA2a; NKA; PMCA; IP3R; titin; N2-B;","animals":null,"cell_lines":null,"links":null,"protocols":null,"wg":"ag_sossalla","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"29":{"id":"29","pmid":"24421331","doi":"10.1083\/jcb.201306077","publication_year":"2014","title":"Human myocytes are protected from titin aggregation-induced stiffening by small heat shock proteins","journal_title":"The Journal of Cell Biology","issn":"0021-9525, 1540-8140","essn":"","url":"http:\/\/jcb.rupress.org\/content\/204\/2\/187","pages":"187-202","issue":"2","volume":"204","journal_abbr":"J Cell Biol","extra":"","publication_type":"unknown","authors":"Sebastian K\u00f6tter, Andreas Unger, Nazha Hamdani, Patrick Lang, Matthias Vorgerd, Luitgard Nagel-Steger, Wolfgang A. Linke,","first_author":"K\u00f6tter","last_author":"Linke","antibody_info":"primary antibodies used were anti-HSP27 (1:250 dilution in PBS; SMC161 5D12; StressMarq), anti-HSP27 (1:200; SR B800; MBL), anti\u2013\u03b1B-crystallin (1:250; SMC 165 3A10; StressMarq), anti\u2013\u03b1B-crystallin (1:400; SR 223F; MBL), anti-titin PEVK (1:200; 9D10; Hybridoma Bank), and anti-titin PEVK (1:500; custom-made, affinity-purified; Eurogentec; Hamdani et al., 2013). Secondary antibodies were Cy3- or FITC-conjugated IgG (1:400; Rockland); primary antibodies against HSP25\/27 (ProteinTech; dilution 1:250 in PBS) or \u03b1B-crystallin (1:500; MLB Antibodies) and counterstained with antibodies against \u03b1-actinin (1:500; Sigma-Aldrich) or myosin-binding protein C (Witt et al., 2001), followed by staining for 1 h with FITC- (Sigma-Aldrich) or Cy3-conjugated (Rockland) secondary antibodies (1:500)","gene_prot":"sHSP; HSP27; \u03b1B-crystallin; titin; PEVK; HSPB1; HSPB5; N2B; N2BA; N2A; N2-A; N2-B; N2-Bus;","animals":null,"cell_lines":"Myofibrils were isolated from thawed human donor heart, rabbit psoas, or rabbit cardiac muscle tissues; human cardiomyocytes;","links":null,"protocols":"Recombinant constructs and site-directed mutagenesis; Ion-exchange chromatography; Analytical ultracentrifugation; Size-exclusion chromatography; GST pulldown assay; Yeast two-hybrid assay; Measurements of mechanical stretch, fluorescence staining, and force in single myofibrils; Prediction of unfolded protein aggregation; In vitro aggregation assays; Cardiomyocyte force measurement; Induction of stretch in rat heart; Human tissues; Immunohistochemistry; Primary cultures of fetal and adult rat cardiomyocytes;","wg":"ag_linke","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"30":{"id":"30","pmid":"25124496","doi":"10.1161\/CIRCULATIONAHA.114.006185","publication_year":"2014","title":"Cardiac CaM Kinase II Genes \u03b4 and \u03b3 Contribute to Adverse Remodeling but Redundantly Inhibit Calcineurin-Induced Myocardial Hypertrophy","journal_title":"Circulation","issn":"1524-4539","essn":"","url":"http:\/\/circ.ahajournals.org\/content\/130\/15\/1262","pages":"1262-1273","issue":"15","volume":"130","journal_abbr":"Circulation","extra":"PMID: 25124496","publication_type":"unknown","authors":"M. M. Kreusser, L. H. Lehmann, S. Keranov, M. O. Hoting, U. Oehl, M. Kohlhaas, J. C. Reil , K. Neumann, M. D. Schneider, J. A. Hill, D. Dobrev, C. Maack, L. S. Maier, H. J. Gr\u00f6ne, H. A. Katus, E. N. Olson, J. Backs,","first_author":"Kreusser","last_author":"Backs","antibody_info":null,"gene_prot":"ANP; BNP; CaMKII; CaMKII\u03b1; CaMKII\u03b2; CaMKII\u03b4; CaMKII\u03b3; RyR2; HDAC4; MEF2; CnA; CnB; NFAT; CnA-\u03b1; CnA-\u03b2; CnA-\u03b21; CnA-Ser411; GAPDH; PLN; \u03b4-CKO; \u03b3-CKO; PLB; phospho-PLB-Thr17; phospho-PLB-Ser16; RCAN1-4; CnA\u03b21; Akt;","animals":"conditional knockout mice containing cardiomyocytespecific deletions of CaMKII\u03b4 (\u03b4-CKO), CaMKII\u03b3 (\u03b3-CKO), or both isoforms (double knockout mice [DKO]); C57BL\/6 mice were obtained from Charles River (wild-type mice);","cell_lines":"Neonatal mouse ventricular myocytes (NMVMs);","links":"http:\/\/circ.ahajournals.org\/content\/suppl\/2014\/08\/14\/CIRCULATIONAHA.114.006185.DC1.html","protocols":"Mouse Experiments; Histology; Western Blotting; GST Pulldown; Immunocytochemistry; CaMKII Kinase Activity; Gene Expression Analysis; RNA isolation; quantitative RT-PCR; Culture of Primary Cardiomyocytes; Epifluorescence Microscopy;","wg":"ag_sossalla","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"31":{"id":"31","pmid":"23064508","doi":"10.1113\/expphysiol.2012.068262","publication_year":"2013","title":"Understanding the physiology of heart failure through cellular and in vivo models-towards targeting of complex mechanisms","journal_title":"Experimental Physiology","issn":"0958-0670, 1469-445X","essn":"","url":"http:\/\/ep.physoc.org\/content\/98\/3\/622","pages":"622-628","issue":"3","volume":"98","journal_abbr":"Exp Physiol","extra":"PMID: 23064508","publication_type":"unknown","authors":"Stephan E. Lehnart,","first_author":"Lehnart","last_author":"Lehnart","antibody_info":null,"gene_prot":"RyR2; SERCA2; PLN; PDE4D; Cx43; SAP97; Nav1.5;","animals":null,"cell_lines":null,"links":null,"protocols":null,"wg":"ag_lehnart","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"32":{"id":"32","pmid":"24625729","doi":"10.1161\/CIRCRESAHA.114.301286","publication_year":"2014","title":"Gigantic business: titin properties and function through thick and thin","journal_title":"Circulation Research","issn":"0009-7330, 1524-4571","essn":"","url":"http:\/\/circres.ahajournals.org\/content\/114\/6\/1052","pages":"1052-1068","issue":"6","volume":"114","journal_abbr":"Circ Res","extra":"","publication_type":"unknown","authors":"Wolfgang A. Linke, Nazha Hamdani,","first_author":"Linke","last_author":"Hamdani","antibody_info":null,"gene_prot":"TTN; titin;","animals":null,"cell_lines":null,"links":null,"protocols":null,"wg":"ag_linke","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"33":{"id":"33","pmid":"23862619","doi":"10.2174\/09298673113209990171","publication_year":"2014","title":"Experimental antiarrhythmic targets: CaMKII inhibition - ready for clinical evaluation?","journal_title":"Current Medicinal Chemistry","issn":"1875-533X","essn":"","url":"http:\/\/www.eurekaselect.com\/112299\/article","pages":"1299-1307","issue":"11","volume":"21","journal_abbr":"Curr Med Chem","extra":"PMID: 23862619","publication_type":"unknown","authors":"Lars S. Maier,","first_author":"Maier","last_author":"Maier","antibody_info":null,"gene_prot":null,"animals":null,"cell_lines":null,"links":null,"protocols":null,"wg":"ag_sossalla","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"34":{"id":"34","pmid":"22767404","doi":"10.1007\/s11897-012-0099-3","publication_year":"2012","title":"New Treatment Options for Late Na Current, Arrhythmias, and Diastolic Dysfunction","journal_title":"Current Heart Failure Reports","issn":"1546-9530, 1546-9549","essn":"","url":"http:\/\/link.springer.com\/article\/10.1007\/s11897-012-0099-3","pages":"183-191","issue":"3","volume":"9","journal_abbr":"Curr Heart Fail Rep","extra":"","publication_type":"unknown","authors":"Lars S. Maier,","first_author":"Maier","last_author":"Maier","antibody_info":null,"gene_prot":"Nav1.1; Nav1.6; SCN5A; Nav1.5; NCX; ACE; CaMKII;","animals":null,"cell_lines":null,"links":"http:\/\/clinicaltrials.gov\/show\/NCT01163734; http:\/\/clinicaltrials.gov\/show\/NCT01534962; http:\/\/clinicaltrials.gov\/show\/NCT01522651;","protocols":null,"wg":"ag_sossalla","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"35":{"id":"35","pmid":"24621836","doi":"10.1016\/j.jchf.2012.12.002","publication_year":"2013","title":"RAnoLazIne for the treatment of diastolic heart failure in patients with preserved ejection fraction: the RALI-DHF proof-of-concept study","journal_title":"JACC. Heart failure","issn":"2213-1787","essn":"","url":"http:\/\/heartfailure.onlinejacc.org\/article.aspx?articleid=1671251","pages":"115-122","issue":"2","volume":"1","journal_abbr":"JACC Heart Fail","extra":"PMID: 24621836","publication_type":"unknown","authors":"Lars S. Maier, Beth Layug,Ewa Karwatowska-Prokopczuk, Luiz Belardinelli, Stella Lee, Julia Sander, Christian Lang, Rolf Wachter, Frank Edelmann,Gerd Hasenfuss, Claudius Jacobshagen,","first_author":"Maier","last_author":"Jacobshagen","antibody_info":null,"gene_prot":null,"animals":null,"cell_lines":null,"links":"http:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT01163734%3fterm=NCT01163734%26rank=1; https:\/\/www.clinicaltrialsregister.eu\/ctr-search\/trial\/2009-017168-17\/DE;","protocols":"Tissue Doppler echocardiography; 12-lead electrocardiography; Cardiopulmonary exercise test (CPET); Exploratory endpoints; LVEDP; intravenous bolus injection and continuous infusion of ranolazine or placebo;","wg":"ag_sossalla","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"36":{"id":"36","pmid":"23500390","doi":"10.1016\/j.yjmcc.2013.03.001","publication_year":"2013","title":"The late Na current as a therapeutic target: where are we?","journal_title":"Journal of Molecular and Cellular Cardiology","issn":"0022-2828, 1095-8584","essn":"","url":"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0022282813000825","pages":"44-50","issue":null,"volume":"61","journal_abbr":"J Mol Cell Cardiol","extra":"PMID: 23500390","publication_type":"unknown","authors":"Lars S. Maier, Samuel Sossalla,","first_author":"Maier","last_author":"Sossalla","antibody_info":null,"gene_prot":"SCN5A; CaMKII; Nav1.5; NCX;","animals":null,"cell_lines":"HEK293 cells;","links":"https:\/\/www.clinicaltrialsregister.eu\/ctr-search\/trial\/2011-004507-20\/DE","protocols":null,"wg":"ag_sossalla","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"37":{"id":"37","pmid":"23810893","doi":"10.1016\/j.jacc.2013.05.057","publication_year":"2013","title":"Phosphodiesterase-2 is up-regulated in human failing hearts and blunts \u03b2-adrenergic responses in cardiomyocytes","journal_title":"Journal of the American College of Cardiology","issn":"1558-3597","essn":"","url":"http:\/\/content.onlinejacc.org\/mobile\/article.aspx?articleid=1700988","pages":"1596-1606","issue":"17","volume":"62","journal_abbr":"J Am Coll Cardiol","extra":"PMID: 23810893","publication_type":"unknown","authors":"Hind Mehel, Julius Emons, Christiane Vettel, Katrin Wittk\u00f6pper, Danilo Seppelt, Matthias Dewenter, Susanne Lutz, Samuel Sossalla, Lars S. Maier, Patrick Lech\u00eane, J\u00e9r\u00f4me Leroy, Florence Lefebvre, Audrey Varin, Thomas Eschenhagen, Stanley Nattel, Dobromir Dobrev, Wolfram-Hubertus Zimmermann, Viacheslav O. Nikolaev, Gr\u00e9goire Vandecasteele, Rodolphe Fischmeister, Ali El-Armouche,","first_author":"Mehel","last_author":"El-Armouche","antibody_info":"anti-ANP (1:200, Santa Cruz), anti-Calsequestrin (1:200, Dianova), anti-PDE2 (1:200, Santa Cruz), anti-Phosphorylated PLB at Ser16 (1:500, Badrilla) and anti-total PLB (1:500, Santa Cruz)","gene_prot":"Phosphodiesterase-2; PDE2; PDE2A2; PDE3; \u03b2-AR; ANP; EGFP;","animals":null,"cell_lines":null,"links":null,"protocols":"preparation of protein extracts; PDE activity assays; myocyte isolation; adenoviral transductions; cAMP measurements by fluorescence resonance energy transfer (FRET); Ca2+ transients; cell shortening; Rat isoprenaline infusion model; Isolation and culture of rat cardiomyocytes; Immunoblot analysis; Real-Time PCR; PDE activity assay; ICa,L current measurements; Measurements of Ca2+ transients and cell shortening; Determination of cellular hypertrophy;","wg":"ag_zimmermann","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"38":{"id":"38","pmid":"23920882","doi":"10.3233\/978-1-61499-289-9-1108","publication_year":"2013","title":"Requirement analysis for an electronic laboratory notebook for sustainable data management in biomedical research","journal_title":"Studies in Health Technology and Informatics","issn":"0926-9630","essn":null,"url":"http:\/\/ebooks.iospress.nl\/publication\/34324","pages":"1108","issue":null,"volume":"192","journal_abbr":"Stud Health Technol Inform","extra":"PMID: 23920882","publication_type":"unknown","authors":"Julia Menzel, Philipp Weil, Philip Bittihn, Daniel Hornung, Nadine Mathieu, Sara Y. Demiroglu,","first_author":"Menzel","last_author":"Demiroglu","antibody_info":null,"gene_prot":null,"animals":null,"cell_lines":null,"links":null,"protocols":null,"wg":"ag_nussbeck","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"39":{"id":"39","pmid":"24600393","doi":"10.3389\/fphar.2014.00020","publication_year":"2014","title":"CaMKII regulation of cardiac K channels","journal_title":"Frontiers in Pharmacology","issn":"1663-9812","essn":"","url":"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3930912\/","pages":"","issue":null,"volume":"5","journal_abbr":"Front Pharmacol","extra":"PMID: 24600393 PMCID: PMC3930912","publication_type":"unknown","authors":"Julian Mustroph, Lars S. Maier, Stefan Wagner,","first_author":"Mustroph","last_author":"Wagner","antibody_info":null,"gene_prot":"RyR2; CaMKII; NCX; CaV1.2; NaV1.5; KV4.2; KV4.3; KV1.4; KCNH2; Kv7.1; KCNQ1; Kv1.5; KCNA5; Kir2.x; hERG; SERCA; CaMKII\u03b4; TNF-\u03b1; KChIP2; KCND2; KCNA4; DPP6; Eps15; EHD4; SAP97; Kir2.1; KCNJ2; Kir2.2; KCNJ12; Kir2.3; KCNJ4; Kir2.4; KCNJ14; Kv4.x; KCNE1;","animals":null,"cell_lines":"HEK-293 cells; rabbit myocytes;","links":null,"protocols":null,"wg":"ag_sossalla","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"40":{"id":"40","pmid":"23740218","doi":"10.1007\/s00395-013-0360-2","publication_year":"2013","title":"Novel aspects of excitation-contraction coupling in heart failure","journal_title":"Basic Research in Cardiology","issn":"1435-1803","essn":"","url":"http:\/\/link.springer.com\/article\/10.1007%2Fs00395-013-0360-2","pages":"360","issue":"4","volume":"108","journal_abbr":"Basic Res Cardiol","extra":"PMID: 23740218","publication_type":"unknown","authors":"Stefan Neef, Lars S. Maier,","first_author":"Neef","last_author":"Maier","antibody_info":null,"gene_prot":"CaMKII; CaMKII\u03b4; PKA; SERCA2a; LTCC; RyR2; PLB; NCX; FKBP12.6; NHE;","animals":null,"cell_lines":null,"links":"https:\/\/www.clinicaltrialsregister.eu\/ctr-search\/trial\/2011-002789-18\/IT; https:\/\/www.clinicaltrialsregister.eu\/ctr-search\/search?query%3Deudract_number:2013-000525-31\u0026page=1033","protocols":null,"wg":"ag_sossalla","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"41":{"id":"41","pmid":"23473775","doi":"10.1016\/j.yjmcc.2013.02.014","publication_year":"2013","title":"While systolic cardiomyocyte function is preserved, diastolic myocyte function and recovery from acidosis are impaired in CaMKII\u03b4-KO mice","journal_title":"Journal of Molecular and Cellular Cardiology","issn":"0022-2828, 1095-8584","essn":"","url":"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0022282813000795#","pages":"107-116","issue":null,"volume":"59","journal_abbr":"J Mol Cell Cardiol","extra":"PMID: 23473775 PMCID: PMC3738196","publication_type":"unknown","authors":"Stefan Neef, Can M. Sag, Maria Daut, Henrik B\u00e4umer, Clemens Grefe, Ali El-Armouche, Jaime DeSantiago, Laetitia Pereira, Donald M. Bers, Johannes Backs, Lars S. Maier","first_author":"Neef","last_author":"Maier","antibody_info":"anti-phopho-CaMKII (1:1,000, Thermo Fisher Scientific), anti-RyR2 (1:10000, Sigma-Aldrich), anti-phospho-RyR2-2809 (1:5,000, Badrilla), anti-phospho-RyR2-2815 (1:5,000, Badrilla), anti-SERCA2a (1:20,000, Affinity Bioreagents), anti-PLB (1:10,000, Millipore), anti-phospho-Ser-16 (1:10,000, Badrilla), anti-phospho-Thr-17 (1:10,000, Badrilla), anti-NCX (1:5000, Swant), anti-I-1 (1:2000, Novus Biologicals), anti-CSQ (1:20000, Affinity Bioreagents), and anti-GAPDH (1:20,000, Biotrend) antibodies.","gene_prot":"CaMKII\u03b4; CaMKII; CaMKII\u03b1; CaMKII\u03b2; CaMKII\u03b3; SERCA; SERCA2a; PLB; RyR; RyR2; NCX; I-1; CSQ; GAPDH;","animals":null,"cell_lines":null,"links":"http:\/\/dx.doi.org\/10.1016\/j.yjmcc.2013.02.014","protocols":"Generation of isoform-specific CaMKII\u03b4-KO; Echocardiography; Isolation of cardiomyocytes; Epifluorescence experiments; CaMKII activity assay; Western blot; Acidosis experiments; Ca2+-spark measurements; Iso experiments; Additional CaMKII\u03b4-KO Mouse Myocytes; [Ca]i measurements;","wg":"ag_sossalla","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"42":{"id":"42","pmid":"24431469","doi":"10.1124\/jpet.113.210898","publication_year":"2014","title":"Paradoxical Effects on Force Generation after Efficient \u03b21-Adrenoceptor Knockdown in Reconstituted Heart Tissue","journal_title":"Journal of Pharmacology and Experimental Therapeutics","issn":"1521-0103","essn":"","url":"http:\/\/jpet.aspetjournals.org\/content\/349\/1\/39","pages":"39-46","issue":"1","volume":"349","journal_abbr":"J Pharmacol Exp Ther","extra":"PMID: 24431469","publication_type":"unknown","authors":"Christiane Neuber, Oliver J. M\u00fcller, Felix C. Hansen, Alexandra Eder, Anika Witten, Frank R\u00fchle, Monika Stoll, Hugo A. Katus, Thomas Eschenhagen, Ali El-Armouche,","first_author":"Neuber","last_author":"El-Armouche","antibody_info":"Immunofluorescence staining was performed with mouse anti-a-actinin monoclonal Ab (1:800) and Alexa Fluor 546 goat anti-mouse IgG secondary Ab (1:800)","gene_prot":"\u03b21-AR; \u03b2-AR; PKA; LTCC; RyR2; PLB; AAV6-shCTR; AAV6-shB1; \u03b21\/\u03b22-AR; ERK;","animals":null,"cell_lines":null,"links":"http:\/\/jpet.aspetjournals.org\/content\/suppl\/2014\/01\/15\/jpet.113.210898.DC1.html","protocols":"Cardiomyocytes and Analysis; Evaluation of siRNA Sequences Targeting \u03b21-AR; Generation of Adeno-Associated Viral Vectors; Engineered Heart Tissue and Analysis; Quantitative Real-Time RT-PCR; Gene Expression Analysis\u2013Microarray Data; \u03b2-Adrenoceptor Density; Histology and Immunochemical Analysis;","wg":"ag_zimmermann","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"43":{"id":"43","pmid":"24833749","doi":"10.15252\/embr.201338358","publication_year":"2014","title":"The laboratory notebook in the 21st century","journal_title":"EMBO reports","issn":"1469-221X, 1469-3178","essn":"","url":"http:\/\/embor.embopress.org\/content\/early\/2014\/05\/15\/embr.201338358","pages":"e201338358","issue":null,"volume":null,"journal_abbr":"EMBO Rep","extra":"Detailed note\u2010keeping is a prerequisite for, if not a key component of, scientific discovery. An unrecorded experiment is lost to the world even if it sparks a great idea in a scientist\u0027s mind: Additional work is needed to reproduce and confirm the original observation and to test the hypothesis by novel experimental strategies. Hence, a detailed record of the experimental setup, observations, and analysis is a crucial requirement for presenting a new discovery to the scientific community. \u003E An unrecorded experiment is lost to the world even if it sparks a great idea in a scientist\u0027s mind\u2026 For centuries, scientists have been using paper notebooks. However, the digital revolution has changed every aspect of data handling: Acquisition has become automated, primary data exist in a huge variety of formats and require vast memory space, and analysis increasingly uses sophisticated software. While electronic note\u2010keeping has become state of the art in the pharmaceutical industry, it is by far not the standard in academic life\u2010science laboratories. In fact, digital record\u2010keeping has been controversial in academia, and hence, its implementation has been lagging. We argue that many academic laboratories will soon abolish the current precarious mixture of digital data and paper\u2010based annotation. We see three main reasons for this trend. First, the vast majority of the data generated by a scientist will be in digital form that has to be documented and archived; however, the paper\u2010based laboratory notebook does not enable convenient documentation of folder structures and data paths. Second, ongoing efforts aim to standardize experimental protocols and data formats in order to improve their general comparability and re\u2010analysis of data, which make standardization more attractive for scientists. In fact, standardization is a prerequisite for using an electronic laboratory notebook (ELN). Third, long\u2010term data storage, an essential component of good scientific practice, easily turns \u2026 PMID: 24833749","publication_type":"unknown","authors":"Sara Y. Nussbeck, Philipp Weil, Julia Menzel, Bartlomiej Marzec, Kai Lorberg, Blanche Schwappach,","first_author":"Nussbeck","last_author":"Schwappach","antibody_info":null,"gene_prot":null,"animals":null,"cell_lines":null,"links":null,"protocols":null,"wg":"ag_schwappach","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"44":{"id":"44","pmid":null,"doi":"10.1109\/ESGCO.2014.6847573","publication_year":"2014","title":"Detecting synchronization and interrelations in multivariate time series","journal_title":"2014 8th Conference of the European Study Group on Cardiovascular Oscillations (ESGCO)","issn":"","essn":"","url":"http:\/\/ieeexplore.ieee.org\/xpl\/articleDetails.jsp?arnumber=6847573","pages":"169-170","issue":null,"volume":null,"journal_abbr":"","extra":"","publication_type":"unknown","authors":"Ulrich Parlitz, Stefan Luther,","first_author":"Parlitz","last_author":"Luther","antibody_info":null,"gene_prot":null,"animals":null,"cell_lines":null,"links":null,"protocols":null,"wg":"ag_luther","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"45":{"id":"45","pmid":"24985465","doi":"10.1063\/1.4884344","publication_year":"2014","title":"Local observability of state variables and parameters in nonlinear modeling quantified by delay reconstruction","journal_title":"Chaos (Woodbury, N.Y.)","issn":"1089-7682","essn":"","url":"http:\/\/scitation.aip.org\/content\/aip\/journal\/chaos\/24\/2\/10.1063\/1.4884344","pages":"024411","issue":"2","volume":"24","journal_abbr":"Chaos","extra":"PMID: 24985465","publication_type":"unknown","authors":"Ulrich Parlitz, Jan Schumann-Bischoff, Stefan Luther,","first_author":"Parlitz","last_author":"Luther","antibody_info":null,"gene_prot":null,"animals":null,"cell_lines":null,"links":null,"protocols":null,"wg":"ag_luther","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"46":{"id":"46","pmid":null,"doi":"10.1103\/PhysRevE.89.050902","publication_year":"2014","title":"Quantifying uncertainty in state and parameter estimation","journal_title":"Physical Review E","issn":"1539-3755, 1550-2376","essn":"","url":"http:\/\/link.aps.org\/doi\/10.1103\/PhysRevE.89.050902","pages":"050902","issue":"5","volume":"89","journal_abbr":"Phys Rev E","extra":"","publication_type":"unknown","authors":"Ulrich Parlitz, Jan Schumann-Bischoff, Stefan Luther,","first_author":"Parlitz","last_author":"Luther","antibody_info":null,"gene_prot":null,"animals":null,"cell_lines":null,"links":null,"protocols":null,"wg":"ag_luther","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"47":{"id":"47","pmid":"23383621","doi":"10.1111\/apha.12077","publication_year":"2013","title":"Compartmentation of cAMP signalling in cardiomyocytes in health and disease","journal_title":"Acta Physiologica (Oxford, England)","issn":"1748-1716","essn":"","url":"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apha.12077\/abstract","pages":"650-662","issue":"4","volume":"207","journal_abbr":"Acta Physiol (Oxf)","extra":"PMID: 23383621","publication_type":"unknown","authors":"R. K. Perera, V. O. Nikolaev,","first_author":"Perera","last_author":"Nikolaev","antibody_info":null,"gene_prot":"GPCR; PKA; LTCCs; RyR2; SERCA; SERCA2A; PLN; \u03b2-AR; \u03b21-AR; \u03b22-AR;  \u03b23-AR; Rap1; Epac; ERK; \u03b2-arrestin; CNG; Epac1; HCN2; AKAP; AKAP9; AKAP75; mAKAP; AKAP15; AKAP18\u03b4; AKAP79; AKAP150; D-AKAP1; AKAP2; AKAP95; AKAP220; AKAP-Lbc; AKAP6; gravin; ezrin; yotiao; PDE; PDE1A; PDE1B; PDE1C; PDE2; PDE2A; PDE2A1; PDE2A2; PDE2A3; PDE3; PDE3A; PDE3B; PDE4D3; PDE4D8; PDE4D5; PDE4B; PP1; PP2; FKBP12.6; calstabin; RII; AC9; calcineurin; NFAT; PI3K\u03b3; \u03b2Arr; HDAC5; eNOS; AC9;","animals":null,"cell_lines":null,"links":null,"protocols":null,"wg":"ag_zimmermann","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"48":{"id":"48","pmid":"24030498","doi":"10.1161\/CIRCULATIONAHA.113.003313","publication_year":"2013","title":"Oxidized Ca2+\/Calmodulin-Dependent Protein Kinase II Triggers Atrial Fibrillation","journal_title":"Circulation","issn":"0009-7322, 1524-4539","essn":"","url":"http:\/\/circ.ahajournals.org\/content\/128\/16\/1748","pages":"1748-1757","issue":"16","volume":"128","journal_abbr":"Circulation","extra":"PMID: 24030498","publication_type":"unknown","authors":"Anil Purohit, Adam G. Rokita, Xiaoqun Guan, Biyi Chen, Olha M. Koval, Niels Voigt, Stefan Neef, Thomas Sowa, Zhan Gao, Elizabeth D. Luczak, Hrafnhildur Stefansdottir, Andrew C. Behunin, Na Li, Ramzi N. El-Accaoui, Baoli Yang, Paari Dominic Swaminathan, Robert M. Weiss, Xander H.T. Wehrens, Long-Sheng Song, Dobromir Dobrev, Lars S. Maier, Mark E. Anderson,","first_author":"Purohit","last_author":"Anderson","antibody_info":"The tissue was incubated overnight in the primary antibody (rabbit anti\u2013mouse ox-CaMKII). ... Denaturated tissue homogenates were subjected to Western blotting (8% SDS-polyacrylamide gels) using anti-CaMKII (1:15000, gift from D. M. Bers, University of California, Davis, CA) and anti-ox-CaMKII (1:15000) antibodies. ... blots were incubated in primary antibodies (ox-CaMKII [1:500] and CaMKII [1:250]) overnight at 4\u00b0C. The same procedure was applied for atrial immunoblots from untreated MsrA transgenic and WT littermate mice incubating with a primary anti-MsrA antibody (1:1000, abcam). Blots were washed in TBS-T and incubated with appropriate HRP-conjugated secondary antibodies","gene_prot":"CaMKII; CaMKII\u03b4; Ang II; MsrA; GAPDH; p47; ATR; NOX; AC3-I;","animals":"C57Bl6 background; p47-\/- mice were purchased from Jackson Labs. Mice with transgenic myocardial CaMKII inhibition (AC3-I), MM-VV knock-in mice and MsrA transgenic mice were generated by our laboratory as described. S2814A knock-in mice were generated by the Wehrens laboratory.","cell_lines":null,"links":"http:\/\/circ.ahajournals.org\/content\/suppl\/2013\/09\/12\/CIRCULATIONAHA.113.003313.DC1.html","protocols":"Human Samples and Immunodetection of ox-CaMKII; Immunofluorescence staining; Immunoblotting for human samples; HR and BP measurements; Mini-osmotic pump implantation; Transthoracic Echocardiography; In vivo Electrophysiology (EP studies); Immunoblotting for mouse samples; ROS detection; Atrial myocyte isolation; Voltage clamp; Ca2+ Imaging;","wg":"ag_sossalla","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"49":{"id":"49","pmid":"23341242","doi":"10.1002\/stem.1332","publication_year":"2013","title":"The four and a half LIM-domain 2 controls early cardiac cell commitment and expansion via regulating \u03b2-catenin-dependent transcription","journal_title":"Stem Cells","issn":"1549-4918","essn":"","url":"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/stem.1332\/abstract","pages":"928-940","issue":"5","volume":"31","journal_abbr":"Stem Cells","extra":"","publication_type":"unknown","authors":"Anke Renger, Maria-Patapia Zafiriou, Claudia Noack, Elena Pavlova, Alexander Becker, Krasimira Sharkova, Martin W. Bergmann, Ali El-Armouche, Wolfram-Hubertus Zimmermann, Laura C. Zelarayan,","first_author":"Renger","last_author":"Zelarayan","antibody_info":"antibodies directed against a-sarcomeric actinin (1:200; Sigma-Aldrich) and Nkx2.5 (1:200; Santa Cruz Biotechnology U.S., Dallas, U.S., http:\/\/www.scbt.com). Cells were stained with anti-rabbit IgGAPC or anti-mouse F(ab)2-FITC (1:500; Jackson Immuno Research U.K., Newmarket, U.K., http:\/\/www.jacksonimmuno.com); anti-b-catenin antibody (Santa Cruz). Detection was done by immunoblotting using a c-myc (Santa Cruz) antibody; anti-FHL2 (Abcam), anti-b-catenin (Santa Cruz) and anti-GAPDH (Zytomed System Germany, Berlin, Germany, http:\/\/www.zytomed-systems.de) antibodies;","gene_prot":"FHL1; FHL3; FHL2; LEF; TCF; Wnt; \u03b2-catenin; Igfbp3; Wnt3a; Igfbp5; Axin; adenomatous polyposis coli 2; GSK-3; \u03b1MHC; GAL4; GAPDH; Hand1; Tbx5; Nkx2.5; cTNT; \u03b1-actinin; KI67; TCF7L2; TCF4; Alpk3; Mef2a; Brachyury; Flk1; Mesp1;","animals":null,"cell_lines":"murine ESCs; cardiomyocytes cells; Neonatal rat cardiomyocytes (NRCMs);","links":null,"protocols":"Yeast-Two-Hybrid; Southern Blot; Cell Culture; Immunofluorescence; Luciferase Reporter Assay; Flow Cytometry Analysis; RNA Isolation, Reverse Transcription, and Quantitative Real-Time PCR Analysis; Coimmunoprecipitation and Immunoblotting;","wg":"ag_zimmermann","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"50":{"id":"50","pmid":"25173923","doi":"10.1016\/j.yjmcc.2014.08.016","publication_year":"2014","title":"Enhanced late INa induces proarrhythmogenic SR Ca leak in a CaMKII-dependent manner","journal_title":"Journal of Molecular and Cellular Cardiology","issn":"1095-8584","essn":"","url":"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0022282814002636","pages":"94-105","issue":null,"volume":null,"journal_abbr":"J Mol Cell Cardiol","extra":"PMID: 25173923","publication_type":"unknown","authors":"Can M. Sag, Anika Mallwitz, StefanWagner, Nico Hartmann, Hanna Schotola, Thomas H. Fischer, Nele Ungeheuer, Jonas Herting, Ajay M. Shah, Lars S.Maier, Samuel Sossalla, Bernhard Uns\u00f6ld,","first_author":"Sag","last_author":"Uns\u00f6ld","antibody_info":"For detection of CaMKII protein expression, we used antibodies kindly provided by Dr. Bers (UCD, California, US). CaMKII-phosphorylation levels were detected using a phosphospecific CaMKII-antibody (1:1000, Thermo \nscientific). Secondary antibodies were purchased from GE Healthcare.","gene_prot":"CaMKII; CaMKII\u03b4C; RAN; TTX; RyR2; GAPDH; SERCA2a; NCX;","animals":null,"cell_lines":"Cardiac myocyte isolation from wild-type (WT) and CaMKII\u03b4C transgenic (TG, i.e. ~3-fold increased activity of CaMKII\u03b4C) hearts having heart failure was performed as reported previously [12].","links":"http:\/\/dx.doi.org\/10.1016\/j.yjmcc.2014.08.016","protocols":"Cardiac myocyte isolation from mouse and failing human hearts; Ca measurements; Patch-clamp experiments; Force measurements in mouse papillary muscles; Pharmacological interventions; Immunoblotting;","wg":"ag_sossalla","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"51":{"id":"51","pmid":"24068185","doi":"10.1007\/s00395-013-0385-6","publication_year":"2013","title":"Ionizing radiation regulates cardiac Ca handling via increased ROS and activated CaMKII","journal_title":"Basic Research in Cardiology","issn":"1435-1803","essn":"","url":"http:\/\/link.springer.com\/article\/10.1007\/s00395-013-0385-6","pages":"385","issue":"6","volume":"108","journal_abbr":"Basic Res Cardiol","extra":"PMID: 24068185  PMCID: PMC3898380","publication_type":"unknown","authors":"Can M. Sag, Hendrik A. Wolff, Kay Neumann, Marie-Kristin Opiela, Juqian Zhang, Felicia Steuer, Thomas Sowa, Shamindra Gupta, Markus Schirmer, Mark H\u00fcnlich, Margret Rave-Fr\u00e4nk, Clemens F. Hess, Mark E. Anderson, Ajay M. Shah, Hans Christiansen, Lars S. Maier,","first_author":"Sag","last_author":"Maier","antibody_info":"For detection of CaMKII protein expression, we used antibodies kindly provided by Dr. Bers, (UCD, Davis, CA, USA). CaMKII-phosphorylation levels were detected using a phosphospecific CaMKII-antibody (1:1,000, Thermo\nscientific). Oxidized CaMKII was detected using an immune serum against oxidized M281\/M282 of CaMKII (ox-CaMKII) [10, 22]. PLB-expression (1:10,000, Millipore) and RyR2-expression (1:10,000, Sigma-Aldrich) were measured along with their individual phosphorylation status at Thr-17 (1:10,000, Badrilla), at Ser-16 (1:10,000, Badrilla, for PLB), at Ser-2809 (1:5,000, Badrilla), and at Ser-2814 (1:5,000, Badrilla, for RyR2). SERCA2a (1:20,000, AffinityBioReagents) and NCX protein expression (Swant 1:5,000) were measured as well. Secondary antibodies were purchased from GE Healthcare.","gene_prot":"CaMKII; PKA; RyR2; PLB; SERCA2a; NCX;","animals":null,"cell_lines":null,"links":null,"protocols":"Irradiation procedure and animal husbandry; Myocyte isolation and culture; Epifluorescence microscopy; Confocal microscopy; Echocardiography; Electron spin resonance spectroscopy; ROS-scavenging and CaMKII-inhibition; Immunoblotting;","wg":"ag_sossalla","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"52":{"id":"52","pmid":"23732518","doi":"10.1016\/j.freeradbiomed.2013.05.035","publication_year":"2013","title":"Role of oxidants on calcium and sodium movement in healthy and diseased cardiac myocytes","journal_title":"Free Radical Biology \u0026 Medicine","issn":"1873-4596","essn":"","url":"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0891584913002451","pages":"338-349","issue":null,"volume":"63","journal_abbr":"Free Radic Biol Med","extra":"PMID: 23732518","publication_type":"unknown","authors":"Can M. Sag, Stefan Wagner, Lars S. Maier,","first_author":"Sag","last_author":"Maier","antibody_info":null,"gene_prot":"PKA; PKC; CaMKII; NOX; RyR2; AKAP; AngII; CaMKIIdC; FKBP12.6; calstabin; LTCC; NaV1.5; NCX1; NHE; NKA; NOS; NOS1; NOS2; iNOS; NOS3; eNOS;NOX; NOX2; NOX4; NOX5; Duox1; Duox2; PLB; PLM; PPI-1; RyR2; SERCA2a; SOD; Trx; XOR; p47; p67; p40; Rac1; p22;","animals":null,"cell_lines":null,"links":null,"protocols":null,"wg":"ag_sossalla","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"53":{"id":"53","pmid":null,"doi":"10.1109\/ESGCO.2014.6847567","publication_year":"2014","title":"Evaluation of machine learning methods for the long-term prediction of cardiac diseases","journal_title":"2014 8th Conference of the European Study Group on Cardiovascular Oscillations (ESGCO)","issn":"","essn":"","url":"http:\/\/ieeexplore.ieee.org\/xpls\/abs_all.jsp?arnumber=6847567","pages":"157-158","issue":null,"volume":null,"journal_abbr":"","extra":"","publication_type":"unknown","authors":"Alexander Schlemmer, Henning Zwirnmann, Markus Zabel, Ulrich Parlitz, Stefan Luther,","first_author":"Schlemmer","last_author":"Luther","antibody_info":"Western blotting was performed as described previously [41] with primary antibodies against ryanodine receptor (RyR, 1:10,000, Sigma-Aldrich), S2843-phosphorylated RyR (1:5,000, Badrilla), Cav1.2 (1:200, Santa Cruz), calsequestrin (CSQ, 1:2,500, Dianova) and GAPDH (1:20,000, Biotrend)","gene_prot":"CaV1.2; LTCC; PLB; SERCA; RyR; CSQ; GAPDH; NCX; CaMKII;","animals":"syngeneic male Lewis rats (270\u00b15 g, n=34, Charles River, Sulzfeld, Germany)","cell_lines":null,"links":null,"protocols":"Isolation of cardiomyocytes; Ca2+ epifluorescence measurements; Cellular electrophysiology; Ca2+ sparks; Western blot analysis;","wg":"ag_luther","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"54":{"id":"54","pmid":"23842739","doi":"10.1007\/s00424-013-1316-y","publication_year":"2013","title":"Enhanced Ca\u00b2+ influx through cardiac L-type Ca\u00b2+ channels maintains the systolic Ca\u00b2+ transient in early cardiac atrophy induced by mechanical unloading","journal_title":"Pfl\u00fcgers Archiv: European Journal of Physiology","issn":"1432-2013","essn":"","url":"http:\/\/link.springer.com\/article\/10.1007%2Fs00424-013-1316-y","pages":"1763-1773","issue":"12","volume":"465","journal_abbr":"Pflugers Arch","extra":"PMID: 23842739  PMCID: PMC3898408","publication_type":"unknown","authors":"A. P. Schwoerer, S. Neef, I. Broichhausen, J. Jacubeit, M. Tiburcy, M. Wagner, D. Biermann, M. Didi\u00e9, C. Vettel, L. S. Maier, W. H. Zimmermann, L. Carrier, T. Eschenhagen,  T. Volk, A. El-Armouche, H. Ehmk,","first_author":"Schwoerer","last_author":"Ehmk","antibody_info":null,"gene_prot":null,"animals":null,"cell_lines":null,"links":null,"protocols":null,"wg":"ag_zimmermann","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"55":{"id":"55","pmid":null,"doi":"10.1109\/ESGCO.2014.6847564","publication_year":"2014","title":"Eliminating pinned spiral waves in cardiac monolayer by far field pacing","journal_title":"2014 8th Conference of the European Study Group on Cardiovascular Oscillations (ESGCO)","issn":"","essn":"","url":"http:\/\/ieeexplore.ieee.org\/xpls\/abs_all.jsp?arnumber=6847564","pages":"151-152","issue":null,"volume":null,"journal_abbr":"","extra":"","publication_type":"unknown","authors":"T K. Shajahan, Valentin I. Krinski, Svetlana Knyazeva, Stefan Luther,","first_author":"Shajahan","last_author":"Luther","antibody_info":null,"gene_prot":null,"animals":null,"cell_lines":null,"links":null,"protocols":null,"wg":"ag_luther","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"56":{"id":"56","pmid":"24550350","doi":"10.1093\/cvr\/cvu029","publication_year":"2014","title":"Control of cytoplasmic and nuclear protein kinase A by phosphodiesterases and phosphatases in cardiac myocytes","journal_title":"Cardiovascular Research","issn":"0008-6363, 1755-3245","essn":"","url":"http:\/\/cardiovascres.oxfordjournals.org\/content\/102\/1\/97","pages":"97-106","issue":"1","volume":"102","journal_abbr":"Cardiovasc Res","extra":"Aims The cAMP-dependent protein kinase (PKA) mediates \u03b2-adrenoceptor (\u03b2-AR) regulation of cardiac contraction and gene expression. Whereas PKA activity is well characterized in various subcellular compartments of adult cardiomyocytes, its regulation in the nucleus remains largely unknown. The aim of the present study was to compare the modalities of PKA regulation in the cytoplasm and nucleus of cardiomyocytes. Methods and results Cytoplasmic and nuclear cAMP and PKA activity were measured with targeted fluorescence resonance energy transfer probes in adult rat ventricular myocytes. \u03b2-AR stimulation with isoprenaline (Iso) led to fast cAMP elevation in both compartments, whereas PKA activity was fast in the cytoplasm but markedly slower in the nucleus. Iso was also more potent and efficient in activating cytoplasmic than nuclear PKA. Similar slow kinetics of nuclear PKA activation was observed upon adenylyl cyclase activation with L-858051 or phosphodiesterase (PDE) inhibition with 3-isobutyl-1-methylxantine. Consistently, pulse stimulation with Iso (15 s) maximally induced PKA and myosin-binding protein C phosphorylation in the cytoplasm, but marginally activated PKA and cAMP response element-binding protein phosphorylation in the nucleus. Inhibition of PDE4 or ablation of the Pde4d gene in mice prolonged cytoplasmic PKA activation and enhanced nuclear PKA responses. In the cytoplasm, phosphatase 1 (PP1) and 2A (PP2A) contributed to the termination of PKA responses, whereas only PP1 played a role in the nucleus. Conclusion Our study reveals a differential integration of cytoplasmic and nuclear PKA responses to \u03b2-AR stimulation in cardiac myocytes. This may have important implications in the physiological and pathological hypertrophic response to \u03b2-AR stimulation. PMID: 24550350","publication_type":"unknown","authors":"Zeineb Haj Slimane, Ibrahim Bedioune, Patrick Lechene, Audrey Varin, Florence Lefebvre, Philippe Mateo, Valerie Domergue-Dupont, Matthias Dewenter, Wito Richter4, Marco Conti, Ali El-Armouche, Jin Zhang, Rodolphe Fischmeister, Gregoire Vandecasteele,","first_author":"Slimane","last_author":"Vandecasteele","antibody_info":"Total and phosphospecific antibodies against CREB and cMyBP-C and a calsequestrin antibody were used as detailed in Supplementary material online. ... antibodies against CREB (Ser133, Cell Signaling Technology) and cMyBP-C (Ser282, Alexis). Immunoreactive proteins were revealed using anti-rabbit IgG conjugated with horseradish peroxidase (Santa Cruz). ... calsequestrin antibody (Affinity BioReagents) used as a loading control or MyBPC3 (K-16) against total cMyBP-C (Santa Cruz). Total CREB was detected with 48H2 antibody (Cell Signaling Techonology)","gene_prot":"PKA; \u03b2-AR; PDE; PDE4; PDE8; Pde4d; PP1; PP2A; PP2B; GsPCR; AC; RyR2; PLB; cMyBP-C; AKAP; CREB; HDAC4; HDAC5; ICUE3; AKAR3;","animals":"Male Wistar rats (200\u2013250 g);","cell_lines":"Adult rat ventricular myocytes (ARVMs)","links":null,"protocols":"FRET-based sensors of cAMP and PKA activity; Isolation of adult rat ventricular myocytes; Adenoviral infection; FRET measurements of cytoplasmic and nuclear cAMP and PKA activity; Western blot studies;","wg":"ag_zimmermann","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"57":{"id":"57","pmid":"24785406","doi":"10.1111\/1755-5922.12078","publication_year":"2014","title":"Effects of ranolazine on torsades de pointes tachycardias in a healthy isolated rabbit heart model","journal_title":"Cardiovascular Therapeutics","issn":"1755-5922","essn":"","url":"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1755-5922.12078\/abstract","pages":"170-177","issue":"4","volume":"32","journal_abbr":"Cardiovasc Ther","extra":"PMID: 24785406","publication_type":"unknown","authors":"Samuel Sossalla, Nora Wallisch, Karl Toischer, Christian Sohns, Dirk Vollmann, Joachim Seegers, Lars L\u00fcthje, Lars S. Maier, Markus Zabel,","first_author":"Sossalla","last_author":"Zabel","antibody_info":null,"gene_prot":"NCX; RyR2;","animals":null,"cell_lines":null,"links":null,"protocols":null,"wg":"ag_sossalla","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"58":{"id":"58","pmid":"23205928","doi":"10.1111\/1755-5922.12017","publication_year":"2013","title":"Ranolazine maintained sinus rhythm in a patient with refractory symptomatic atrial fibrillation","journal_title":"Cardiovascular Therapeutics","issn":"1755-5922","essn":"","url":"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1755-5922.12017\/abstract","pages":"303-306","issue":"5","volume":"31","journal_abbr":"Cardiovasc Ther","extra":"PMID: 23205928","publication_type":"unknown","authors":"Samuel Sossalla, Christian Sohns, Joachim Seegers, Lars L\u00fcthje, Dirk Vollmann, Markus Zabel,","first_author":"Sossalla","last_author":"Zabel","antibody_info":null,"gene_prot":null,"animals":null,"cell_lines":null,"links":null,"protocols":null,"wg":"ag_sossalla","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"59":{"id":"59","pmid":"23606651","doi":"10.1177\/1087057113486000","publication_year":"2013","title":"Development of a colorimetric and a fluorescence phosphatase-inhibitor assay suitable for drug discovery approaches","journal_title":"Journal of Biomolecular Screening","issn":"1087-0571, 1552-454X","essn":"","url":"http:\/\/jbx.sagepub.com\/content\/18\/8\/899","pages":"899-909","issue":"8","volume":"18","journal_abbr":"J Biomol Screen","extra":"","publication_type":"unknown","authors":"Hannieh Sotoud, Philip Gribbon, Bernhard Ellinger, Jeanette Reinshagen, Peter Boknik, Lars Kattner, Ali El-Armouche, Thomas Eschenhagen,","first_author":"Sotoud","last_author":"Eschenhagen","antibody_info":null,"gene_prot":"PP; PP1c; PP1; PKA; DARPP-32; IUP; PLB; RyR;","animals":null,"cell_lines":null,"links":null,"protocols":null,"wg":"ag_zimmermann","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"60":{"id":"60","pmid":"23584022","doi":"10.3390\/ijms14048025","publication_year":"2013","title":"Biophysical Techniques for Detection of cAMP and cGMP in Living Cells","journal_title":"International Journal of Molecular Sciences","issn":"1422-0067","essn":"","url":"http:\/\/www.mdpi.com\/1422-0067\/14\/4\/8025","pages":"8025-8046","issue":"4","volume":"14","journal_abbr":"Int J Mol Sci","extra":"PMID:23584022","publication_type":"unknown","authors":"Julia U. Sprenger, Viacheslav O. Nikolaev,","first_author":"Sprenger","last_author":"Nikolaev","antibody_info":null,"gene_prot":"CNGC; PKA; CREB; TnI; PLN; GC; pGC; sGC; BNP; CNP; PKG; PDE; PDE2; PDE3; PDE4; PDE5; AKAP; RII; AKAR1; AKAR2; AKAR3; AKAR4; Epac1; Epac2; \u03b21-AR; \u03b22-AR; \u03b1-FlincG; \u03b2-FlincG; \u03b4-FlincG; Hsp20;","animals":null,"cell_lines":null,"links":null,"protocols":null,"wg":"ag_zimmermann","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"61":{"id":"61","pmid":"22798560","doi":"10.1093\/eurheartj\/ehs203","publication_year":"2013","title":"Comparative study of human-induced pluripotent stem cells derived from bone marrow cells, hair keratinocytes, and skin fibroblasts","journal_title":"European Heart Journal","issn":"0195-668X, 1522-9645","essn":"","url":"http:\/\/eurheartj.oxfordjournals.org\/content\/34\/33\/2618","pages":"2618-2629","issue":"33","volume":"34","journal_abbr":"Eur Heart J","extra":"PMID: 22798560","publication_type":"unknown","authors":"Katrin Streckfuss-B\u00f6meke, Frieder Wolf, Azadeh Azizian, Michael Stauske, Malte Tiburcy, Stefan Wagner, Daniela H\u00fcbscher, Ralf Dressel, Simin Chen, J\u00f6rg Jende, Gerald Wulf, Verena Lorenz, Michael P. Sch\u00f6n, Lars S. Maier, Wolfram H. Zimmermann, Gerd Hasenfuss, Kaomei Guan,","first_author":"Streckfuss-B\u00f6meke","last_author":"Guan","antibody_info":null,"gene_prot":"OCT4; NANOG; SOX2; LIN28; GAPDH; HES3; SSEA4; Tra-1-60;","animals":null,"cell_lines":null,"links":null,"protocols":"Isolation and cultivation of hair keratinocytes, bone marrow mesenchymal stem cells, and skin fibroblasts; Generation and characterization of human-induced pluripotent stem cells; In vitro differentiation; Electrophysiology and measurement of Ca21 transients; Generation of circular EHTs;","wg":"ag_guan","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"62":{"id":"62","pmid":"25717475","doi":"10.1016\/j.ebiom.2014.11.005","publication_year":"2014","title":"Induction of Tet3-dependent epigenetic remodeling by low-dose Hydralazine attenuates progression of chronic kidney disease","journal_title":"EBioMedicine","issn":"2352-3964","essn":"","url":"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S2352396414000292","pages":"","issue":null,"volume":null,"journal_abbr":"","extra":"","publication_type":"unknown","authors":"Bj\u00f6rn Tampe, Desiree Tampe, Elisabeth M. Zeisberg, Gerhard A. M\u00fcller, Wibke Bechtel-Walz, Michael Koziolek, Raghu Kalluri, Michael Zeisberg,","first_author":"Tampe","last_author":"Zeisberg","antibody_info":"primary antibodies against \u03b1-smooth muscle actin (\u03b1SMA, Abcam, Cambridge, UK) and fibroblast-specific protein 1 (Fsp1, Sigma, St. Louis, USA), and Alexa Fluor 568 (Invitrogen, Carlsbad, USA) secondary antibodies were used; primary antibodies against Dnmt1 (B-Bridge, Cupertino, USA), Tet3 (Genetex, San Antonio, USA), Tdg (Santa Cruz Biotechnology, Santa Cruz, USA), HIF1\u03b1 (Invitrogen, Carlsbad, USA), \u03b2-actin (Sigma, St. Louis, USA) and Gapdh (HyTest, Turku, Finland), secondary HRP-conjugated antibodies were used (Dako, Glostrup, Denmark).","gene_prot":"RASAL1; Tet3; Tdg; HIF1\u03b1; DNMT1; GAPDH; \u03b1SMA; Fsp1; Hif1\u03b1; Aicda; Apobec1; Tdg; Smug1;","animals":"twelve weeks\u2013old CD57BL\/6 mice; CD1 mice; rtTAhCMV;hRASAL1-pTreTight transgenic mice;","cell_lines":"Primary murine kidney fibroblasts;","links":null,"protocols":"Unilateral ureteral obstruction (UUO); Folic acid\u2013induced nephropathy (FA); rtTAhCMV;hRASAL1-pTreTight transgenic mice; Histology; Immunofluorescence; Serum creatinine measurement; Cell culture; In vitro transfection; RNA isolation; Quantitative real-time PCR quantification (qRT-PCR); DNA isolation; Isolation of methylated, hydroxymethylated, carboxylated DNA; SYBR-based amplification of methylated, hydroxymethylated, carboxylated Rasal1\/RASAL1; Methylation-specific PCR; Western blot analyses;","wg":"ag_zeisberg","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"63":{"id":"63","pmid":"25070336","doi":"10.1007\/978-1-4939-1047-2_15","publication_year":"2014","title":"Collagen-Based Engineered Heart Muscle","journal_title":"Methods in molecular biology","issn":"1940-6029","essn":"","url":"http:\/\/link.springer.com\/protocol\/10.1007\/978-1-4939-1047-2_15","pages":"167-176","issue":null,"volume":null,"journal_abbr":"Methods Mol Biol","extra":"PMID: 25070336 DOI: 10.1007\/978-1-4939-1047-2_15","publication_type":"unknown","authors":"Malte Tiburcy, Tim Meyer, Poh Loong Soong, Wolfram-Hubertus Zimmermann,","first_author":"Tiburcy","last_author":"Zimmermann","antibody_info":null,"gene_prot":null,"animals":null,"cell_lines":null,"links":null,"protocols":null,"wg":"ag_zimmermann","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"64":{"id":"64","pmid":"23953977","doi":"10.1016\/j.tcm.2013.05.003","publication_year":"2014","title":"Modeling myocardial growth and hypertrophy in engineered heart muscle","journal_title":"Trends in Cardiovascular Medicine","issn":"1873-2615","essn":"","url":"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S1050173813000820","pages":"7-13","issue":"1","volume":"24","journal_abbr":"Trends Cardiovasc Med","extra":"PMID: 23953977","publication_type":"unknown","authors":"Malte Tiburcy, Wolfram-Hubertus Zimmermann,","first_author":"Tiburcy","last_author":"Zimmermann","antibody_info":null,"gene_prot":"VEGF-AA; HIF-1\u03b1; PHD2; PDH3; MEK; ERK; ERK1; ERK2;","animals":null,"cell_lines":null,"links":null,"protocols":null,"wg":"ag_zimmermann","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"65":{"id":"65","pmid":"23570977","doi":"10.1016\/j.yjmcc.2013.03.021","publication_year":"2013","title":"Role of late sodium current as a potential arrhythmogenic mechanism in the progression of pressure-induced heart disease","journal_title":"Journal of Molecular and Cellular Cardiology","issn":"0022-2828, 1095-8584","essn":"","url":"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0022282813001028","pages":"111-122","issue":null,"volume":"61","journal_abbr":"J Mol Cell Cardiol","extra":"PMID: 23570977  PMCID: PMC3720777","publication_type":"unknown","authors":"Karl Toischer, Nico Hartmann, Stefan Wagner, Thomas H. Fischer, Jonas Herting, Bernhard C. Danner, Can M. Sag, Thomas J. Hund, Peter J. Mohler, Luiz Belardinelli, Gerd Hasenfuss, Lars S. Maier, Samuel Sossalla,","first_author":"Toischer","last_author":"Sossalla","antibody_info":"The antibodies used are shown in the online supplement. ... anti-Nav1.1 (1:500; alomone labs, Jerusalem, Israel), anit-Nav1.5 (1:2000;alomone labs, Jerusalem, Israel), anti-phospho-Nav1.5 (1:2000, Peter Mohler) anti-Nav1.6 (1:1000; alomone labs, Jerusalem, Israel), anti-SCN1B (1:2000; cellapplications, San Diego, CA USA), anti- CaMKII\u03b4 (1:1000, a gift from D. Bers) [8] and anti phospho-CaMKII\u03b4 (1:1000; Thermo scientific\/Piere Antibodies, Rockford, USA) as primary and an HRP-conjugated donkey anti-rabbit IgG (1:5000; Amersham Biosciences, Freiburg, Germany) as secondary antibody. Glycerinaldehyde-3-phosphate-dehydrogenase (GAPDH) was used a house keeping proteins with the anti-GAPDH (1:100,000, Biotrend Chemikalien GmbH, K\u00f6ln, Germany) as primary and an HRP-conjugated sheep anti-mouse IgG (1:20000; Amersham Biosciences, Freiburg, Germany) as secondary antibody.","gene_prot":"CaMKII; RyR2; NCX; Nav1.1; Nav1.5; Nav1.6; SCN1B; CaMKII\u03b4; GAPDH;","animals":"8 weeks old female C57\/BL6J mice","cell_lines":"Cardiomyocytes","links":"http:\/\/dx.doi.org\/10.1016\/j.yjmcc.2013.03.021","protocols":"Transverse aortic constriction (TAC) and echocardiography; Cell isolation; Patch-clamp experiments; Confocal microscopy; Western blots;","wg":"ag_sossalla","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"66":{"id":"66","pmid":"24135075","doi":"10.1124\/jpet.113.207001","publication_year":"2014","title":"Dopamine and Lipophilic Derivates Protect Cardiomyocytes against Cold Preservation Injury","journal_title":"Journal of Pharmacology and Experimental Therapeutics","issn":"1521-0103","essn":"","url":"http:\/\/jpet.aspetjournals.org\/content\/348\/1\/77","pages":"77-85","issue":"1","volume":"348","journal_abbr":"J Pharmacol Exp Ther","extra":"PMID: 24135075","publication_type":"unknown","authors":"Christiane Vettel, Maximilia C. Hottenrott, Rahel Spindler, Urs Benck, Peter Schnuelle, Charalambos Tsagogiorgas, Bernhard K. Kr\u00e4mer, Simone Hoeger, Ali El-Armouche, Thomas Wieland, and Benito A. Yard,","first_author":"Vettel","last_author":"Yard","antibody_info":null,"gene_prot":"LDH;","animals":null,"cell_lines":"Neonatal Rat Cardiomyocytes","links":"http:\/\/jpet.aspetjournals.org\/content\/suppl\/2013\/10\/17\/jpet.113.207001.DC1.html","protocols":"Isolation and Culture of Neonatal Rat Cardiomyocetes; Synthesis of Chemical Compounds; Lactate Dehydrogenase Assay; Assessment of Intracellular ATP Amount; Determination of cAMP Formation; Determination of Cardiomyocyte Contractility; Cold Preservation of and LDH Measurement in Explanted Rat Hearts;","wg":"ag_zimmermann","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"67":{"id":"67","pmid":"24531807","doi":"10.1152\/ajpheart.00852.2013","publication_year":"2014","title":"PDE2-mediated cAMP hydrolysis accelerates cardiac fibroblast to myofibroblast conversion and is antagonized by exogenous activation of cGMP signaling pathways","journal_title":"American Journal of Physiology. Heart and Circulatory Physiology","issn":"0363-6135, 1522-1539","essn":"","url":"http:\/\/ajpheart.physiology.org\/content\/306\/8\/H1246","pages":"H1246-H1252","issue":"8","volume":"306","journal_abbr":"Am J Physiol Heart Circ Physiol","extra":"Recent studies suggest that the signal molecules cAMP and cGMP have antifibrotic effects by negatively regulating pathways associated with fibroblast to myofibroblast (MyoCF) conversion. The phosphodiesterase 2 (PDE2) has the unique property to be stimulated by cGMP, which leads to a remarkable increase in cAMP hydrolysis and thus mediates a negative cross-talk between both pathways. PDE2 has been recently investigated in cardiomyocytes; here we specifically addressed its role in fibroblast conversion and cardiac fibrosis. PDE2 is abundantly expressed in both neonatal rat cardiac fibroblasts (CFs) and cardiomyocytes. The overexpression of PDE2 in CFs strongly reduced basal and isoprenaline-induced cAMP synthesis, and this decrease was sufficient to induce MyoCF conversion even in the absence of exogenous profibrotic stimuli. Functional stress-strain experiments with fibroblast-derived engineered connective tissue (ECT) demonstrated higher stiffness in ECTs overexpressing PDE2. In regard to cGMP, neither basal nor atrial natriuretic peptide-induced cGMP levels were affected by PDE2, whereas the response to nitric oxide donor sodium nitroprusside was slightly but significantly reduced. Interestingly, despite persistently depressed cAMP levels, both cGMP-elevating stimuli were able to completely prevent the PDE2-induced MyoCF phenotype, arguing for a double-tracked mechanism. In conclusion, PDE2 accelerates CF to MyoCF conversion, which leads to greater stiffness in ECTs. Atrial natriuretic peptide- and sodium nitroprusside-mediated cGMP synthesis completely reverses PDE2-induced fibroblast conversion. Thus PDE2 may augment cardiac remodeling, but this effect can also be overcome by enhanced cGMP. The redundant role of cAMP and cGMP as antifibrotic meditators may be viewed as a protective mechanism in heart failure. PMID: 24531807","publication_type":"unknown","authors":"C. Vettel, S. L\u00e4mmle, S. Ewens, C. Cervirgen, J. Emons, A. Ongherth, M. Dewenter, D. Lindner, D. Westermann, V. O. Nikolaev,S. Lutz, W. H. Zimmermann, A. El-Armouche,","first_author":"Vettel","last_author":"El-Armouche","antibody_info":"The following antibodies were used: anti-\u03b1-smooth muscle-actin (1:2,000), anti- -tubulin (1:2,000) from Sigma-Aldrich, anti-PDE2 (1:200), anti-procollagen type1A1 (1:200), anti-CTGF (1:200), anti-GAPDH (1:1,000) from Santa Cruz Biotechnology, and anti-calsequestrin (1:2,500) from ThermoScientific.","gene_prot":"PDE2; \u03b1-SMA; ANP; \u03b2-AR; Procollagen I; GAPDH; CSQ; CTGF; SNP; TGF-\u03b2;","animals":null,"cell_lines":null,"links":null,"protocols":"Animal care and culture of rat neonatal cardiac cells; Engineered connective tissues and recombinant adenoviruses; Immunoblot, immunofluorescence, cAMP\/cGMP detection;","wg":"ag_zimmermann","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"68":{"id":"68","pmid":"23047121","doi":"10.1016\/j.bbamcr.2012.09.012","publication_year":"2014","title":"Lysine methyltransferase Smyd2 regulates Hsp90-mediated protection of the sarcomeric titin springs and cardiac function","journal_title":"Biochimica et Biophysica Acta","issn":"0167-4889","essn":"","url":"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0167488912002819","pages":"812-822","issue":"4","volume":"1833","journal_abbr":"Biochim Biophys Acta","extra":"","publication_type":"unknown","authors":"Tobias Voelkel, Christian Andresen, Andreas Unger, Steffen Just, Wolfgang Rottbauer, Wolfgang A. Linke,","first_author":"Voelkel","last_author":"Linke","antibody_info":null,"gene_prot":"Hsp90; Smyd1; Smyd2; Smyd2a; Smyd2b; Smyd3; Smyd4; N2A; titin; p53; RB; KMT; H3K36; PEVK; \u03b1-actinin; ACT2; Hsp90alpha; P07901; P07900; P11499; Hsp90beta; P08238;","animals":"neonatal (day 2) Wistar Unilever rat; C57Bl\/6 mice","cell_lines":"Cardiomyocytes; Embryonic chick cardiomyocytes;","links":"http:\/\/dx.doi.org\/10.1016\/j.bbamcr.2012.09.012","protocols":"Isolation and primary culture of neonatal rat cardiomyocytes; Primary culture of embryonic chick cardiomyocytes; Adult mouse heart sections; Immunohistochemistry; Mechanical manipulation and fluorescence staining of isolated cardiac myofibrils; Antibodies; Glutathione S-transferase (GST) pulldown binding assay; Yeast two-hybrid screen;","wg":"ag_linke","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"69":{"id":"69","pmid":"25350293","doi":"10.3791\/51823","publication_year":"2014","title":"Analysis of Tubular Membrane Networks in Cardiac Myocytes from Atria and Ventricles","journal_title":"Journal of Visualized Experiments","issn":"1940-087X","essn":"","url":"http:\/\/www.jove.com\/video\/51823\/analysis-tubular-membrane-networks-cardiac-myocytes-from-atria","pages":"","issue":"92","volume":null,"journal_abbr":"J Vis Exp","extra":"","publication_type":"unknown","authors":"Eva Wagner, S\u00f6ren Brandenburg, Tobias Kohl, Stephan E. Lehnart,","first_author":"Wagner","last_author":"Lehnart","antibody_info":null,"gene_prot":null,"animals":null,"cell_lines":null,"links":null,"protocols":null,"wg":"ag_lehnart","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"70":{"id":"70","pmid":"25073061","doi":"10.1016\/j.yjmcc.2014.07.011","publication_year":"2014","title":"NADPH oxidase 2 mediates angiotensin II-dependent cellular arrhythmias via PKA and CaMKII","journal_title":"Journal of Molecular and Cellular Cardiology","issn":"0022-2828","essn":"","url":"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0022282814002363","pages":"206-215","issue":null,"volume":"75","journal_abbr":"J Mol Cell Cardiol","extra":"","publication_type":"unknown","authors":"Stefan Wagner, Christian Dantz, Hannah Flebbe, Azadeh Azizian, Can Martin Sag, Susanne Engels, Johanna M\u00f6llencamp, Nataliya Dybkova, Towhidul Islam, Ajay M. Shah, Lars S. Maier,","first_author":"Wagner","last_author":"Maier","antibody_info":null,"gene_prot":null,"animals":null,"cell_lines":null,"links":null,"protocols":null,"wg":"ag_sossalla","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"71":{"id":"71","pmid":"22900788","doi":"10.1089\/ars.2012.4818","publication_year":"2013","title":"Redox regulation of sodium and calcium handling","journal_title":"Antioxidants \u0026 Redox Signaling","issn":"1557-7716","essn":"","url":"http:\/\/online.liebertpub.com\/doi\/abs\/10.1089\/ars.2012.4818","pages":"1063-1077","issue":"9","volume":"18","journal_abbr":"Antioxid Redox Signal","extra":"PMID: 22900788  PMCID: PMC3567778","publication_type":"unknown","authors":"Stefan Wagner, Adam G. Rokita, Mark E. Anderson, Lars S. Maier,","first_author":"Wagner","last_author":"Maier","antibody_info":null,"gene_prot":null,"animals":null,"cell_lines":null,"links":null,"protocols":null,"wg":"ag_sossalla","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"72":{"id":"72","pmid":"23395736","doi":"10.1016\/j.hrthm.2013.02.002","publication_year":"2013","title":"Small conductance Ca-activated K channel: Small but powerful proarrhythmogenic?","journal_title":"Heart Rhythm","issn":"1547-5271","essn":"","url":"http:\/\/www.heartrhythmjournal.com\/article\/S1547527113001082\/abstract","pages":"899-900","issue":"6","volume":"10","journal_abbr":"Heart Rhythm","extra":"","publication_type":"unknown","authors":"Stefan Wagner, Lars S. Maier,","first_author":"Wagner","last_author":"Maier","antibody_info":null,"gene_prot":null,"animals":null,"cell_lines":null,"links":null,"protocols":null,"wg":"ag_hasenfuss","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"73":{"id":"73","pmid":"22723297","doi":"10.1161\/CIRCRESAHA.112.274530","publication_year":"2012","title":"Stimulated Emission Depletion Live-Cell Super-Resolution Imaging Shows Proliferative Remodeling of T-Tubule Membrane Structures After Myocardial Infarction","journal_title":"Circulation Research","issn":"0009-7330, 1524-4571","essn":"","url":"http:\/\/circres.ahajournals.org\/content\/111\/4\/402","pages":"402-414","issue":"4","volume":"111","journal_abbr":"Circ Res","extra":"PMID: 22723297","publication_type":"unknown","authors":"Eva Wagner, Marcel A. Lauterbach, Tobias Kohl, Volker Westphal, George S. B. Williams, Julia H. Steinbrecher, Jan-Hendrik Streich, Brigitte Korff, Hoang-Trong M. Tuan, Brian Hagen, Stefan Luther, Gerd Hasenfuss, Ulrich Parlitz, M. Saleet Jafri, Stefan W. Hell, W. Jonathan Lederer, Stephan E. Lehnart,","first_author":"Wagner","last_author":"Lehnart","antibody_info":"antibodies and dilutions: anti-junctophilin-2 1:1000 (Invitrogen 40-5300), anti-caveolin-3 1:2000 (Abcam ab2912), anti-RyR2 1:2500 (Prestige, Sigma), anti-GAPDH 1:40,000 (Biotrend 5G4MAB6C5). After three washes, membranes were incubated with horseradish peroxidase labeled anti-rabbit or anti-mouse IgG 1:10,000 for 1 h at room temperature (GE Healthcare NA934 \u0026 NXA931)","gene_prot":"RyR2; LCC; NCX; SERCA; SERCA2a; Cav3; Jph2;","animals":null,"cell_lines":null,"links":"http:\/\/circres.ahajournals.org\/content\/suppl\/2012\/06\/21\/CIRCRESAHA.112.274530.DC1.html","protocols":"STED Microscopy Image Acquisition; Quantitative STED Image Analysis of TT Cross-Sections; Skeleton and Spatial Orientation Analysis; Computational Modeling of Local Ca2 Release Function;","wg":"ag_lehnart","subproject":"","open_access":"2","peer_reviewed":null,"creation_time":"2019-06-06 09:13:28"},"74":{"id":"74","pmid":"25015964","doi":"10.1152\/ajpheart.00694.2013","publication_year":"2014","title":"Urocortin 2 stimulates nitric oxide production in ventricular myocytes via Akt- and PKA-mediated phosphorylation of eNOS at serine 1177","journal_title":"American Journal of Physiology. Heart and Circulatory Physiology","issn":"0363-6135, 1522-1539","essn":"","url":"http:\/\/ajpheart.physiology.org\/content\/307\/5\/H689","pages":"H689-H700","issue":"5","volume":"307","journal_abbr":"Am J Physiol Heart Circ Physiol","extra":"Urocortin 2 (Ucn2) is a cardioactive peptide exhibiting beneficial effects in normal and failing heart. In cardiomyocytes, it elicits cAMP- and Ca2+-dependent positive inotropic and lusitropic effects. We tested the hypothesis that, in addition, Ucn2 activates cardiac nitric oxide (NO) signaling and elucidated the underlying signaling pathways and mechanisms. In isolated rabbit ventricular myocytes, Ucn2 caused concentration- and time-dependent increases in phosphorylation of Akt (Ser473, Thr308), endothelial NO synthase (eNOS) (Ser1177), and ERK1\/2 (Thr202\/Tyr204). ERK1\/2 phosphorylation, but not Akt and eNOS phosphorylation, was suppressed by inhibition of MEK1\/2. Increased Akt phosphorylation resulted in increased Akt kinase activity and was mediated by corticotropin-releasing factor 2 (CRF2) receptors (astressin-2B sensitive). Inhibition of phosphatidylinositol 3-kinase (PI3K) diminished both Akt as well as eNOS phosphorylation mediated by Ucn2. Inhibition of protein kinase A (PKA) reduced Ucn2-induced phosphorylation of eNOS but did not affect the increase in phosphorylation of Akt. Conversely, direct receptor-independent elevation of cAMP via forskolin increased phosphorylation of eNOS but not of Akt. Ucn2 increased intracellular NO concentration ([NO]i), [cGMP], [cAMP], and cell shortening. Inhibition of eNOS suppressed the increases in [NO]i and cell shortening. When both PI3K-Akt and cAMP-PKA signaling were inhibited, the Ucn2-induced increases in [NO]i and cell shortening were attenuated. Thus, in rabbit ventricular myocytes, Ucn2 causes activation of cAMP-PKA, PI3K-Akt, and MEK1\/2-ERK1\/2 signaling. The MEK1\/2-ERK1\/2 pathway is not required for stimulation of NO signaling in these cells. The other two pathways, cAMP-PKA and PI3K-Akt, converge on eNOS phosphorylation at Ser1177 and result in pronounced and sustained cellular NO production with subsequent stimulation of cGMP signaling. PMID: 25015964","publication_type":"unknown","authors":"Stefanie Walther, Florentina Pluteanu, Susanne Renz, Yulia Nikonova, Joshua T. Maxwell, Li-Zhen Yang, Kurt Schmidt, Joshua N. Edwards, Paulina Wakula, Klaus Groschner, Lars S. Maier, Joachim Spiess, Lothar A. Blatter, Burkert Pieske, Jens Kocksk\u00e4mper,","first_author":"Walther","last_author":"Kocksk\u00e4mper","antibody_info":"Blots were\nincubated overnight at 4\u00b0C with primary antibodies: rabbit polyclonal\nanti-phospho-Akt (Ser473; 1:1,000; Cell Signaling), rabbit\npolyclonal anti-phospho-Akt (Thr308; 1:1,000; Cell Signaling),\nrabbit polyclonal anti-phospho-eNOS (Ser1177; 1:750; Cell Signaling), mouse monoclonal anti-phospho-p44\/42-MAPK (Thr202\/Tyr204) antibody (1:7,000), or mouse monoclonal anti-GAPDH (1:40,000; Bio-Trend). Membranes were washed three times with blotting buffer and then incubated (1 h, RT) with secondary antibodies (donkey anti-rabbit Ig-HRP-linked antibody, 1:3,000; or sheep antimouse IgG-HRP-linked antibody, 1:10,000; Amersham).","gene_prot":"Ucn1; Ucn2; Ucn3; Akt; eNOS; ERK1; ERK2; CRF2; PI3K; PKA; MEK1; MEK2; p38; MAPK; p44; p42; CRF; GAPDH; CaMKII; \u03b22-AR; PDK; ANP; BNP; PDE; PDE2; PDE3;","animals":"Rabbits","cell_lines":null,"links":null,"protocols":"Isolation of ventricular myocytes; Immunoblot studies; Akt kinase activity; Measuring DAF-FM fluorescence (NO) and cell shortening; Conversion of DAF-FM fluorescence intensity into the rate of NO production; cGMP and cAMP measurements;","wg":"ag_sossalla","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"75":{"id":"75","pmid":"24345421","doi":"10.1016\/j.yjmcc.2013.12.003","publication_year":"2014","title":"Caveolin-3 regulates compartmentation of cardiomyocyte beta2-adrenergic receptor-mediated cAMP signaling","journal_title":"Journal of Molecular and Cellular Cardiology","issn":"0022-2828, 1095-8584","essn":"","url":"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0022282813003520","pages":"38-48","issue":null,"volume":"67","journal_abbr":"J Mol Cell Cardiol","extra":"PMID: 24345421","publication_type":"unknown","authors":"Peter T.Wright, Viacheslav O. Nikolaev, Thomas O\u0027Hara, Ivan Diakonov, Anamika Bhargava, Sergiy Tokar, Sophie Schobesberger, Andrew I. Shevchuk, Markus B. Sikkel, Ross Wilkinson, Natalia A. Trayanova, Alexander R. Lyon, Sian E. Harding, Julia Gorelik,","first_author":"Wright","last_author":"Gorelik","antibody_info":"primary monoclonal Cav3 antibodies (1:5000, Santa Cruz Biotech, USA) overnight at 4 \u00b0C. After washing, the blots were probed with a 1:5000 dilution of horseradish peroxidase (HRP)-conjugated anti-mouse IgG (Sigma, St Louis, MO, USA)","gene_prot":"\u03b2AR; \u03b21AR; \u03b22AR; CAMKII; Cav3; Epac2; PKI; PKA; GAPDH;","animals":"Adult male Sprague\u2013Dawley rats (250\u2013300 g)","cell_lines":"Myocytes fromhealthy or failing hearts","links":"http:\/\/dx.doi.org\/10.1016\/j.yjmcc.2013.12.003","protocols":"Heart failure model and cell isolation; Electron microscopy; Western blot analysis; Radioligand binding studies; FRET imaging of cAMP in living cardiac myocytes; SICM and SICM\/FRET experiments; Electrophysiological recordings from adult cardiac myocytes;","wg":"ag_zimmermann","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"76":{"id":"76","pmid":"24030022","doi":"10.1161\/CIRCRESAHA.113.300216","publication_year":"2013","title":"Patching the Heart Cardiac Repair From Within and Outside","journal_title":"Circulation Research","issn":"0009-7330, 1524-4571","essn":"","url":"http:\/\/circres.ahajournals.org\/content\/113\/7\/922","pages":"922-932","issue":"7","volume":"113","journal_abbr":"Circ Res","extra":"PMID: 24030022","publication_type":"unknown","authors":"Lei Ye, Wolfram-Hubertus Zimmermann, Daniel J Garry, Jianyi Zhang,","first_author":"Ye","last_author":"Zhang","antibody_info":null,"gene_prot":null,"animals":null,"cell_lines":null,"links":null,"protocols":null,"wg":"ag_zimmermann","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"77":{"id":"77","pmid":"24806289","doi":"10.1002\/stem.1741","publication_year":"2014","title":"Erythropoietin responsive cardiomyogenic cells contribute to heart repair post myocardial infarction","journal_title":"Stem Cells","issn":"1549-4918","essn":"","url":"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/stem.1741\/abstract","pages":"2480-2491","issue":"9","volume":"32","journal_abbr":"Stem Cells","extra":"PMID: 24806289","publication_type":"unknown","authors":"Maria Patapia Zafiriou, Claudia Noack, Bernhard Uns\u00f6ld, Michael Didie, Elena Pavlova, Henrike J. Fischer, Holger M. Reichardt, Martin W. Bergmann, Ali El-Armouche, Wolfram-Hubertus Zimmermann, Laura Cecilia Zelarayan,","first_author":"Zafiriou","last_author":"Zelarayan","antibody_info":null,"gene_prot":"Epo; EPOR; TBX5; NKX2.5; MHC; cTNT; GAPDH; AKT;","animals":"neonatal (P1, P3, P6, P10, and P13), and adult NMRI mice; 20 weeks old C57BL\/6 female mice;","cell_lines":null,"links":null,"protocols":"RNA Isolation, Reverse Transcription, and Quantitative PCR Analysis; Immunoblot Analysis; Immunohistochemistry; CPC Isolation, SCA1, and EPOR Magnetic Cell Sorting; Flow Cytometry; Adult Cardiac Fibroblast Isolation and Preparation of Conditioned Medium; Cell Culture; Immunocytochemistry; Proliferation Assays; Myocardial Infarction; Echocardiography;","wg":"ag_zimmermann","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"78":{"id":"78","pmid":"23097091","doi":"10.1002\/path.4120","publication_year":"2013","title":"The role of promoter hypermethylation in fibroblast activation and fibrogenesis","journal_title":"Journal of Pathology","issn":"1096-9896","essn":"","url":"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/path.4120\/abstract","pages":"264-273","issue":"2","volume":"229","journal_abbr":"J Pathol","extra":"PMID: 23097091","publication_type":"unknown","authors":"Elisabeth M Zeisberg, Michael Zeisberg,","first_author":"Zeisberg","last_author":"Zeisberg","antibody_info":null,"gene_prot":"RASAL1; FLI1; PPAR\u03b3; TGF\u03b21; \u03b11\u03b21 integrin; DDR-2; MBD; UHRF; MeCP2; MBD1; MBD6; MeCP2; HIPK2; Np95; ICBP90; Kaiso; ZBTB4; ZBT38; DLG2; Enc; EYA1; Lzts1; HIPK1; HIPK2; HIPK3; Lrnf2; Odd1; Pax3; Zu5; Lrnf2; GTP\u2013Ras; \u03b1-SMA; Akt; PkB; FLI1; Smad4; Pten; E-cadherin; Klotho; p14; ARF; FlI1; Thy-1; PTGER2; Dnmt1; Dnmt3a; Dnmt3b; SAM; Tet1; Tet2; Tet3; CDH1; CDH13; ER\u03b1; NOR1; NPM2; OLIG2; p15INK4B; PGRA; PGRB; RIL; AID; APOBEC; TDG;","animals":null,"cell_lines":null,"links":null,"protocols":null,"wg":"ag_zeisberg","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"79":{"id":"79","pmid":"25111226","doi":"10.1016\/j.ajpath.2014.06.014","publication_year":"2014","title":"Thrombospondin-1 deficiency causes a shift from fibroproliferative to inflammatory kidney disease and delays onset of renal failure","journal_title":"The American Journal of Pathology","issn":"0002-9440","essn":"","url":"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0002944014003691","pages":"2687-2698","issue":"10","volume":"184","journal_abbr":"Am J Pathol","extra":"","publication_type":"unknown","authors":"Michael Zeisberg, Bj\u00f6rn Tampe, Valerie LeBleu, Desiree Tampe, Elisabeth M. Zeisberg, Raghu Kalluri,","first_author":"Zeisberg","last_author":"Kalluri","antibody_info":"primary antibodies: \u03b1SMA and GPR44 (LifeSpan BioSciences); CD45 (BD Biosciences, San Jose, CA); CCR5, IL-13, ROR-g, and FOXP3 (Abcam, Cambridge, MA); and TSP1 and p-SMAD2\/3 (Santa Cruz Biotechnology, Dallas, TX); primary antibodies to CD31 and collagen IV. Collagen IV antibodies were raised against the noncollagenous domain of type IV collagen and therefore detected all type IV collagen isoforms, including collagen IV \u03b11 and\/or \u03b12 chains, which are abundantly present in the Col4a3 KO and Col4a3;Tsp1 KO mice.","gene_prot":"TSP1; TGF-\u03b21; \u03b1SMA; CD45; CCR5; GPR44; RAR; ROR-\u03b3; FOXP3; SMAD2; SMAD3;","animals":"Col4a3 KO mice and Tsp1 KO mice, both on a C57BL\/6 background, have been described previously.","cell_lines":"Primary renal fibroblasts were isolated from kidneys of C57BL\/6 wild-type mice and of Tsp1 KO mice","links":null,"protocols":"Histological Analysis; Staining Procedures; Preparation of Primary Renal Fibroblasts; Proliferation Assay; Quantification of Fibrillar Collagen Content; RNA Isolation and Quantitative Real-Time PCR;","wg":"ag_zeisberg","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"80":{"id":"80","pmid":"24229468","doi":"10.1186\/scrt348","publication_year":"2013","title":"Biomechanical regulation of in vitro cardiogenesis for tissue-engineered heart repair","journal_title":"Stem Cell Research \u0026 Therapy","issn":"1757-6512","essn":"","url":"http:\/\/stemcellres.com\/content\/4\/6\/137\/abstract","pages":"137","issue":"6","volume":"4","journal_abbr":"Stem Cell Res Ther","extra":"","publication_type":"unknown","authors":"Wolfram-Hubertus Zimmermann,","first_author":"Zimmermann","last_author":"Zimmermann","antibody_info":null,"gene_prot":null,"animals":null,"cell_lines":null,"links":null,"protocols":null,"wg":"ag_zimmermann","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"81":{"id":"81","pmid":"25713289","doi":"10.1161\/JAHA.115.001770","publication_year":"2015","title":"Endothelial p53 deletion improves angiogenesis and prevents cardiac fibrosis and heart failure induced by pressure overload in mice.","journal_title":"Journal of the American Heart Association","issn":null,"essn":"2047-9980","url":"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=25713289%5Buid%5D","pages":null,"issue":"2","volume":"4","journal_abbr":"J Am Heart Assoc","extra":null,"publication_type":"unknown","authors":"Gogiraju R, Xu X, Bochenek ML, Steinbrecher JH, Lehnart SE, Wenzel P, Kessel M, Zeisberg EM, Dobbelstein M, Sch\u00e4fer K","first_author":"Gogiraju R","last_author":"Sch\u00e4fer K","antibody_info":null,"gene_prot":null,"animals":null,"cell_lines":null,"links":null,"protocols":null,"wg":"ag_schaefer","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"82":{"id":"82","pmid":"25688144","doi":"10.1161\/CIRCRESAHA.116.306082","publication_year":"2015","title":"Microdomain switch of cGMP-regulated phosphodiesterases leads to ANP-induced augmentation of \u03b2-adrenoceptor-stimulated contractility in early cardiac hypertrophy.","journal_title":"Circulation 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ML","last_author":"Zimmermann WH","antibody_info":null,"gene_prot":null,"animals":null,"cell_lines":null,"links":null,"protocols":null,"wg":"ag_zimmermann","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 09:09:20"},"91":{"id":"91","pmid":null,"doi":"10.3205\/mibe000162","publication_year":"2015","title":"Metadata capture in an electronic notebook: How to make it as simple as possible?","journal_title":"GMS Medizinische Informatik, Biometrie und Epidemiologie","issn":"1860-9171","essn":"","url":"http:\/\/www.egms.de\/static\/de\/journals\/mibe\/2015-11\/mibe000162.shtml","pages":"Doc06","issue":"1","volume":"11","journal_abbr":"GMS Med Inform Biom Epidemiol","extra":"","publication_type":"unknown","authors":"Menzel J, Weil P, Nussbeck SY","first_author":"Menzel J","last_author":"Nussbeck 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09:09:20"},"93":{"id":"93","pmid":"26291556","doi":"10.1161\/CIRCRESAHA.115.306985","publication_year":"2015","title":"Human Engineered Heart Muscles Engraft and Survive Long-Term in a Rodent Myocardial Infarction Model.","journal_title":"Circulation research","issn":"0009-7330","essn":"1524-4571","url":"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=26291556%5Buid%5D","pages":"","issue":null,"volume":null,"journal_abbr":"Circ Res","extra":"","publication_type":"unknown","authors":"Riegler J, Tiburcy M, Ebert A, Tzatzalos E, Raaz U, Abilez OJ, Shen Q, Kooreman NG, Neofytou E, Chen V, Wang M, Meyer T, Tsao PS, Connolly AJ, Couture LA, Gold JD, Zimmermann WH, Wu JC","first_author":"Riegler J, Tiburcy M","last_author":"Wu JC, Zimmermann WH","antibody_info":null,"gene_prot":null,"animals":null,"cell_lines":null,"links":null,"protocols":null,"wg":"ag_zimmermann","subproject":null,"open_access":"2","peer_reviewed":null,"creation_time":"2018-05-17 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