| Property |
Value |
| Working Groups |
|
| Subproject |
None |
| Open Access |
Unknown |
| Publication Type |
Unknown |
| Peer Reviewed |
Unknown |
| PMID |
23771692 |
| DOI |
10.1152/ajpheart.00218.2013 |
| Publication Year |
2013 |
| Title |
Preservation of left ventricular function and morphology in volume-loaded versus volume-unloaded heterotopic heart transplants
|
| Journal |
American Journal of Physiology. Heart and Circulatory Physiology |
| ISSN |
0363-6135, 1522-1539 |
| URL |
http://ajpheart.physiology.org/content/305/4/H533 |
| Pages |
H533-H541 |
| Issue |
4 |
| Volume |
305 |
| Journal Abbreviation |
Am J Physiol Heart Circ Physiol |
| Extra |
Total mechanical unloading of the heart in classical models of heterotopic heart transplantation leads to cardiac atrophy and functional deterioration. In contrast, partial unloading of failing human hearts with left ventricular (LV) assist devices (LVADs) can in some patients ameliorate heart failure symptoms. Here we tested in heterotopic rat heart transplant models whether partial volume-loading (VL; anastomoses: aorta of donor to aorta of recipient, pulmonary artery of donor to left atrium of donor, superior vena cava of donor to inferior vena cava of recipient; n = 27) is superior to the classical model of myocardial unloading (UL; anastomoses: aorta of donor to aorta of recipient, pulmonary artery of donor to inferior vena cava of recipient; n = 14) with respect to preservation of ventricular morphology and function. Echocardiography, magnetic resonance imaging, and LV-pressure-volume catheter revealed attenuated myocardial atrophy with ∼30% higher LV weight and better systolic contractile function in VL compared with UL (fractional area shortening, 34% vs. 18%; maximal change in pressure over time, 2,986 ± 252 vs. 2,032 ± 193 mmHg/s). Interestingly, no differences in fibrosis (Picrosirus red staining) or glucose metabolism (2-[18F]-fluoro-2-deoxy-D-glucose-PET) between VL and UL were observed. We conclude that the rat model of partial VL attenuates atrophic remodelling and shows superior morphological as well as functional preservation, and thus should be considered more widely as a research model. PMID: 23771692 |
| Authors |
Michael Didié, Daniel Biermann, Ralph Buchert, Andreas Hess, Katrin Wittköpper, Peter Christalla, Stephan Döker, Fawad Jebran, Friedrich Schöndube, Hermann Reichenspurner, Ali El-Armouche, Wolfram-Hubertus Zimmermann |
| First Author |
Didie |
| Last Author |
Zimmermann |
| Scholia |
Wikidata-based representation at Scholia |
External Resources
Q44729878https://www.wikidata.org/wiki/Q44729878 Wikidata ID